Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Plasmodium falciparum | M18 aspartyl aminopeptidase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0041 | 0.4424 | 0.4415 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.4424 | 0.4415 |
Plasmodium vivax | M18 aspartyl aminopeptidase, putative | 0.0087 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.4424 | 0.4415 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0087 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.3942 | 0.3942 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0456 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.3703 | 0.5 | |
Mycobacterium leprae | PROBABLE AMINOPEPTIDASE PEPC | 0.0087 | 1 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0804 | 0.0271 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.3942 | 0.3591 |
Mycobacterium tuberculosis | Probable aminopeptidase PepC | 0.0087 | 1 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0456 | 0.0441 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0087 | 1 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0456 | 0.0441 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.3703 | 0.3153 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0107 | 0.0107 |
Plasmodium falciparum | M18 aspartyl aminopeptidase | 0.0087 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.3703 | 0.3165 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Loa Loa (eye worm) | aspartyl aminopeptidase | 0.0087 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.3703 | 0.3703 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0087 | 1 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0804 | 0.0271 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.8409 | 0.8409 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0456 | 0.0441 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0548 | 0.0548 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0456 | 0.0441 |
Echinococcus granulosus | aspartyl aminopeptidase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Entamoeba histolytica | aminopeptidase, putative | 0.0087 | 1 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.3942 | 0.3942 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0456 | 0.0441 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0087 | 1 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MH, Family M20 | 0.0087 | 1 | 0.5 |
Entamoeba histolytica | aspartyl aminopeptidase, putative | 0.0087 | 1 | 1 |
Leishmania major | aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 | 0.0087 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.4424 | 0.4415 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0041 | 0.4424 | 0.4415 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.7458 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0041 | 0.4424 | 0.4415 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0456 | 0.0441 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0456 | 0.0441 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.3942 | 0.3591 |
Echinococcus multilocularis | aspartyl aminopeptidase | 0.0087 | 1 | 1 |
Trypanosoma cruzi | aspartyl aminopeptidase, putative | 0.0087 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0456 | 0.0441 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0456 | 0.0441 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0041 | 0.4424 | 0.4415 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.127 um | PUBCHEM_BIOASSAY: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). (Class of assay: confirmatory) [Related PubChem assays: 2170 (Confirmation screen (PFM18AAP inhibitors).), 1855 (Summary AID.)] | ChEMBL. | No reference |
IC50 (binding) | > 59.642 um | PUBCHEM_BIOASSAY: QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). (Class of assay: confirmatory) [Related pubchem assays: 2178 (Confirmation screen (PFM18AAP inhibitors).), 1855 (Summary AID.)] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.