Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | chromobox protein | 0.0427 | 0.2028 | 0.1914 |
Schistosoma mansoni | hypothetical protein | 0.071 | 0.3599 | 0.3507 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0247 | 0.1026 | 0.1527 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0063 | 0 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0991 | 0.5167 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0297 | 0.1302 | 0.1139 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0297 | 0.1302 | 0.1139 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0208 | 0.0806 | 0.1147 |
Plasmodium vivax | JmjC domain containing protein | 0.0063 | 0 | 0.5 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0247 | 0.1026 | 0.1527 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0991 | 0.5167 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.113 | 0.5941 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0202 | 0.0772 | 0.064 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0835 | 0.4294 | 0.7161 |
Loa Loa (eye worm) | hypothetical protein | 0.0991 | 0.5167 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.113 | 0.5941 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0835 | 0.4294 | 0.7161 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0208 | 0.0806 | 0.0674 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0576 | 0.2856 | 0.4682 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0576 | 0.2856 | 0.2754 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.071 | 0.3599 | 0.5962 |
Loa Loa (eye worm) | mbt repeat family protein | 0.06 | 0.2986 | 0.5001 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0208 | 0.0806 | 0.1147 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0576 | 0.2856 | 0.4682 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0835 | 0.4294 | 0.4212 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0208 | 0.0806 | 0.1147 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0202 | 0.0772 | 0.064 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0576 | 0.2856 | 0.2754 |
Toxoplasma gondii | PLU-1 family protein | 0.0095 | 0.0179 | 1 |
Brugia malayi | mbt repeat family protein | 0.06 | 0.2986 | 0.5001 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0168 | 0.0585 | 0.0766 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0202 | 0.0772 | 0.1089 |
Echinococcus granulosus | chromobox protein 2 | 0.0427 | 0.2028 | 0.3253 |
Echinococcus multilocularis | chromobox protein 2 | 0.0427 | 0.2028 | 0.3253 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0208 | 0.0806 | 0.1147 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.071 | 0.3599 | 0.5962 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 15.84893192 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Potency (ADMET) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.