TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 225.136 | Formula: C6H12NO6P
H donors: 3 H acceptors: 5 LogP: -4.97 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COP(=O)(CC(=O)CC(C(=O)O)N)O
InChi: 1S/C6H12NO6P/c1-13-14(11,12)3-4(8)2-5(7)6(9)10/h5H,2-3,7H2,1H3,(H,9,10)(H,11,12)
InChiKey: YGBBYQRWHPGKOE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Glutamate NMDA receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	heat shock protein, putative	0.0878	0.3972	0.3972
Leishmania major	heat shock protein 83-1	0.2142	1	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0067	0.0106	0.0106
Schistosoma mansoni	heat shock protein	0.2142	1	1
Leishmania major	heat shock protein 83-1	0.2142	1	1
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0436	0.1867	0.2358
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0436	0.1867	0.4701
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0436	0.1867	0.1867
Leishmania major	heat shock protein, putative	0.0878	0.3972	0.3972
Trypanosoma brucei	heat shock protein, putative	0.2142	1	1
Trypanosoma cruzi	heat shock protein 90, putative	0.1264	0.5815	0.5815
Leishmania major	heat shock protein 83-1	0.2142	1	1
Trichomonas vaginalis	heat shock protein, putative	0.1314	0.6052	0.6052
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0436	0.1867	0.2358
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0067	0.0106	0.0106
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.1706	0.792	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0337	0.1396	0.1396
Trypanosoma brucei	heat shock protein 84, putative	0.0878	0.3972	0.3972
Trichomonas vaginalis	heat shock protein, putative	0.1706	0.792	0.792
Loa Loa (eye worm)	hypothetical protein	0.0293	0.1184	0.1184
Treponema pallidum	heat shock protein 90	0.1706	0.792	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0067	0.0106	0.0106
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0067	0.0106	0.0106
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0436	0.1867	0.2358
Brugia malayi	Probable DNA topoisomerase II	0.0436	0.1867	0.1867
Toxoplasma gondii	heat shock protein HSP90	0.2142	1	1
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.1706	0.792	0.792
Brugia malayi	kinase, mitochondrial precursor	0.0436	0.1867	0.1867
Leishmania major	heat shock protein 83-1	0.2142	1	1
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0436	0.1867	0.1867
Plasmodium falciparum	DNA gyrase subunit B	0.0436	0.1867	0.1867
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0337	0.1396	0.1396
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0098	0.0254	0.0254
Trypanosoma brucei	heat shock protein 90, putative	0.2142	1	1
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0878	0.3972	1
Leishmania major	DNA topoisomerase ii	0.0436	0.1867	0.1867
Plasmodium vivax	heat shock protein 86, putative	0.2142	1	1
Giardia lamblia	Grp94/Hsp90	0.1706	0.792	0.792
Trypanosoma brucei	heat shock protein, putative	0.2142	1	1
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0436	0.1867	0.1867
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0436	0.1867	0.2358
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0436	0.1867	0.2358
Trichomonas vaginalis	sensor histidine kinase, putative	0.0436	0.1867	0.1867
Mycobacterium ulcerans	putative regultory protein	0.0436	0.1867	0.2358
Trichomonas vaginalis	endoplasmin, putative	0.1314	0.6052	0.6052
Leishmania major	mitochondrial DNA topoisomerase II	0.0436	0.1867	0.1867
Chlamydia trachomatis	DNA gyrase subunit B	0.0436	0.1867	1
Mycobacterium ulcerans	two component sensor kinase MprB	0.0436	0.1867	0.2358
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0067	0.0106	0.0106
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0436	0.1867	0.1867
Leishmania major	heat shock protein 83-1	0.2142	1	1
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0436	0.1867	0.1867
Echinococcus granulosus	heat shock protein	0.2142	1	1
Brugia malayi	heat shock protein 90	0.2142	1	1
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0436	0.1867	0.2358
Echinococcus granulosus	voltage gated potassium channel	0.0098	0.0254	0.0254
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0067	0.0106	0.0106
Echinococcus multilocularis	heat shock protein 90	0.2142	1	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0067	0.0106	0.0106
Leishmania major	heat shock protein 83-1	0.2142	1	1
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0436	0.1867	0.1867
Echinococcus multilocularis	heat shock protein	0.2142	1	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0067	0.0106	0.0106
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0315	0.129	0.129
Trypanosoma cruzi	heat shock protein 85, putative	0.1706	0.792	0.792
Brugia malayi	Hsp90 protein	0.0878	0.3972	0.3972
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0436	0.1867	0.2358
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0098	0.0254	0.0254
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0436	0.1867	0.1867
Schistosoma mansoni	endoplasmin	0.2142	1	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0067	0.0106	0.0106
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0067	0.0106	0.0106
Plasmodium falciparum	DNA topoisomerase 2	0.0436	0.1867	0.1867
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0436	0.1867	0.1867
Plasmodium falciparum	heat shock protein 90, putative	0.0878	0.3972	0.3972
Mycobacterium tuberculosis	Conserved protein	0.0436	0.1867	0.2358
Plasmodium vivax	heat shock protein, putative	0.0878	0.3972	0.3972
Schistosoma mansoni	voltage-gated potassium channel	0.0368	0.1544	0.1544
Echinococcus granulosus	heat shock protein 90	0.1706	0.792	0.792
Plasmodium vivax	heat shock protein 90, putative	0.0878	0.3972	0.3972
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0067	0.0106	0.0106
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.1706	0.792	1
Schistosoma mansoni	voltage-gated potassium channel	0.0098	0.0254	0.0254
Schistosoma mansoni	voltage-gated potassium channel	0.0098	0.0254	0.0254
Plasmodium vivax	endoplasmin, putative	0.2142	1	1
Trypanosoma brucei	heat shock protein, putative	0.2142	1	1
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0436	0.1867	0.2358
Echinococcus multilocularis	voltage gated potassium channel	0.0098	0.0254	0.0254
Leishmania major	heat shock protein 83-1	0.2142	1	1
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0436	0.1867	0.2358
Schistosoma mansoni	DNA topoisomerase II	0.0436	0.1867	0.1867
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0436	0.1867	0.2358
Leishmania major	heat shock protein 83-1	0.2142	1	1
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0436	0.1867	0.2358
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0436	0.1867	0.1867
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0436	0.1867	0.1867
Leishmania major	heat shock protein 83-1	0.2142	1	1
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0436	0.1867	0.1867
Toxoplasma gondii	heat shock protein 90, putative	0.2142	1	1
Trypanosoma cruzi	heat shock protein 85, putative	0.2142	1	1
Trypanosoma brucei	heat shock protein 90, putative	0.2142	1	1
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0878	0.3972	0.3972
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0436	0.1867	0.1867
Toxoplasma gondii	Hsp90 domain-containing protein	0.0878	0.3972	0.3972
Trichomonas vaginalis	heat shock protein, putative	0.2142	1	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0067	0.0106	0.0106
Trypanosoma brucei	heat shock protein, putative	0.2142	1	1
Plasmodium vivax	DNA gyrase subunit B, putative	0.0436	0.1867	0.1867
Loa Loa (eye worm)	heat shock protein 90	0.2142	1	1
Mycobacterium leprae	Probable two-component sensor kinase	0.0436	0.1867	0.2358
Schistosoma mansoni	heat shock protein	0.2142	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0067	0.0106	0.0106
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0436	0.1867	0.1867
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0436	0.1867	0.2358
Trypanosoma brucei	Heat shock protein 83, putative	0.2142	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0067	0.0106	0.0106
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0436	0.1867	0.1867
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0067	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0254	0.0254
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0436	0.1867	0.1867
Schistosoma mansoni	voltage-gated potassium channel	0.0067	0.0106	0.0106
Trichomonas vaginalis	heat shock protein, putative	0.1706	0.792	0.792
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0436	0.1867	0.1867
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.1706	0.792	0.792
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0436	0.1867	0.2358
Loa Loa (eye worm)	TOPoisomerase family member	0.0436	0.1867	0.1867
Chlamydia trachomatis	DNA gyrase subunit B	0.0436	0.1867	1
Leishmania major	heat shock protein 83-1	0.2142	1	1
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0436	0.1867	0.1867
Trypanosoma brucei	heat shock protein, putative	0.2142	1	1
Trypanosoma brucei	heat shock protein, putative	0.2142	1	1
Trichomonas vaginalis	receptor histidine kinase, putative	0.0436	0.1867	0.1867
Toxoplasma gondii	heat shock protein 75, putative	0.0878	0.3972	0.3972
Leishmania major	heat shock protein 83-1	0.2142	1	1
Schistosoma mansoni	heat shock protein	0.0878	0.3972	0.3972
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0098	0.0254	0.0254
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0436	0.1867	0.1867
Leishmania major	heat shock protein 83-1	0.2142	1	1
Entamoeba histolytica	heat shock protein 90, putative	0.2142	1	1
Plasmodium falciparum	heat shock protein 90, putative	0.0878	0.3972	0.3972
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0067	0.0106	0.0106
Schistosoma mansoni	voltage-gated potassium channel	0.0368	0.1544	0.1544
Leishmania major	heat shock protein 83-1	0.2142	1	1
Trichomonas vaginalis	heat shock protein, putative	0.1706	0.792	0.792
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0436	0.1867	0.1867
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0067	0.0106	0.0106
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0436	0.1867	0.4701
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0315	0.129	0.129
Trypanosoma cruzi	heat shock protein, putative	0.0878	0.3972	0.3972
Leishmania major	heat shock protein 83-1	0.2142	1	1
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0436	0.1867	0.2358
Trypanosoma brucei	heat shock protein, putative	0.2142	1	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0067	0.0106	0.0106
Loa Loa (eye worm)	endoplasmin	0.2142	1	1
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0436	0.1867	0.1867
Plasmodium falciparum	heat shock protein 90	0.2142	1	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0067	0.0106	0.0106
Trypanosoma brucei	DNA topoisomerase ii	0.0436	0.1867	0.1867
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0436	0.1867	0.1867
Entamoeba histolytica	heat shock protein 90, putative	0.2142	1	1
Echinococcus granulosus	endoplasmin	0.1706	0.792	0.792
Giardia lamblia	Heat shock protein HSP 90-alpha	0.2142	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0337	0.1396	0.1396
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0878	0.3972	0.3972
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0436	0.1867	0.2358
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0436	0.1867	0.1867
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0436	0.1867	0.2358
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0436	0.1867	0.1867
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.1706	0.792	1
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0436	0.1867	0.2358
Loa Loa (eye worm)	hypothetical protein	0.0436	0.1867	0.1867
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0436	0.1867	0.2358
Schistosoma mansoni	voltage-gated potassium channel	0.0053	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0436	0.1867	0.1867
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0436	0.1867	1
Giardia lamblia	Heat shock protein HSP 90-alpha	0.1706	0.792	0.792
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0436	0.1867	0.2358
Leishmania major	heat shock protein 83-1	0.2142	1	1
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0436	0.1867	0.1867
Schistosoma mansoni	60S ribosomal protein L21	0.0053	0.0041	0.0041
Trypanosoma brucei	heat shock protein, putative	0.2142	1	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0067	0.0106	0.0106
Leishmania major	heat shock protein 83-1	0.2142	1	1
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0436	0.1867	0.2358
Echinococcus multilocularis	endoplasmin	0.1706	0.792	0.792
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0436	0.1867	0.2358
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0436	0.1867	0.1867
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0436	0.1867	0.1867
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0436	0.1867	0.1867
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0436	0.1867	0.4701
Plasmodium falciparum	endoplasmin, putative	0.1314	0.6052	0.6052
Giardia lamblia	Pms1-like protein	0.0436	0.1867	0.1867
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0436	0.1867	0.2358
Loa Loa (eye worm)	heat shock protein 75	0.0878	0.3972	0.3972
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0436	0.1867	0.1867
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0878	0.3972	0.2588
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0436	0.1867	0.2358
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0436	0.1867	0.1867
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0436	0.1867	0.2358
Loa Loa (eye worm)	hypothetical protein	0.0436	0.1867	0.1867
Trypanosoma cruzi	heat shock protein 85, putative	0.2142	1	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0106	0.0106
Trypanosoma cruzi	Heat shock protein 83, putative	0.2142	1	1
Plasmodium vivax	DNA topoisomerase II, putative	0.0436	0.1867	0.1867
Schistosoma mansoni	pyruvate dehydrogenase	0.0436	0.1867	0.1867
Mycobacterium ulcerans	DNA gyrase subunit B	0.0436	0.1867	0.2358
Leishmania major	heat shock protein 83-1	0.2142	1	1
Mycobacterium ulcerans	heat shock protein 90	0.1706	0.792	1
Leishmania major	hypothetical protein, conserved	0.0436	0.1867	0.1867
Trypanosoma cruzi	heat shock protein 90, putative	0.1706	0.792	0.792
Trypanosoma cruzi	heat shock protein 90, putative	0.2142	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0337	0.1396	0.1396
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0436	0.1867	0.2358
Schistosoma mansoni	endoplasmin	0.2142	1	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0067	0.0106	0.0106
Echinococcus multilocularis	heat shock protein 90	0.1706	0.792	0.792
Plasmodium vivax	hypothetical protein, conserved	0.0436	0.1867	0.1867
Trichomonas vaginalis	receptor histidine kinase, putative	0.0436	0.1867	0.1867
Trypanosoma cruzi	heat shock protein 85, putative	0.2142	1	1
Echinococcus granulosus	heat shock protein 90	0.2142	1	1
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0436	0.1867	0.2358
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0436	0.1867	0.2358

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5 uM	Tested for the binding potency against NMDA site of the glutamate receptor complex using rat brain cortical membranes in a competitive binding assay with [3H]-CPP as radioligand	ChEMBL.	No reference
IC50 (binding)	= 5 uM	Tested for the binding potency against NMDA site of the glutamate receptor complex using rat brain cortical membranes in a competitive binding assay with [3H]-CPP as radioligand	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 143775