Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | zinc finger protein | 0.3967 | 0.9133 | 0.9057 |
Leishmania major | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0374 | 0.0808 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0374 | 0.0808 | 1 |
Onchocerca volvulus | 0.0374 | 0.0808 | 0.5 | |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0374 | 0.0808 | 1 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0374 | 0.0808 | 1 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0374 | 0.0808 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0374 | 0.0808 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.0374 | 0.0808 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.0808 | 0.0808 |
Brugia malayi | Hhat protein | 0.0374 | 0.0808 | 0.0808 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0374 | 0.0808 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.0808 | 0.0808 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0374 | 0.0808 | 1 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.0808 | 0.0808 |
Brugia malayi | MBOAT family protein | 0.0374 | 0.0808 | 0.0808 |
Brugia malayi | diacylglycerol acyltransferase | 0.0374 | 0.0808 | 0.0808 |
Brugia malayi | MBOAT family protein | 0.0374 | 0.0808 | 0.0808 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0374 | 0.0808 | 0.5 |
Loa Loa (eye worm) | hhat protein | 0.0374 | 0.0808 | 0.0808 |
Toxoplasma gondii | hypothetical protein | 0.0374 | 0.0808 | 1 |
Trichomonas vaginalis | porcupine, putative | 0.0374 | 0.0808 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0374 | 0.0808 | 0.0808 |
Leishmania major | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Loa Loa (eye worm) | hhat protein | 0.0374 | 0.0808 | 0.0808 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0374 | 0.0808 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0374 | 0.0808 | 0.5 |
Brugia malayi | MBOAT family protein | 0.0374 | 0.0808 | 0.0808 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0374 | 0.0808 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.3967 | 0.9133 | 0.9057 |
Schistosoma mansoni | zinc finger protein | 0.4341 | 1 | 1 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0374 | 0.0808 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.4341 | 1 | 1 |
Loa Loa (eye worm) | MBOAT family protein | 0.0374 | 0.0808 | 0.0808 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.221 | 0.1525 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.0808 | 0.0808 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.4341 | 1 | 1 |
Trypanosoma cruzi | GUP1, putative | 0.0374 | 0.0808 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0374 | 0.0808 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.4341 | 1 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0374 | 0.0808 | 1 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0374 | 0.0808 | 0.0808 |
Loa Loa (eye worm) | MBOAT family protein | 0.0374 | 0.0808 | 0.0808 |
Brugia malayi | MBOAT family protein | 0.0374 | 0.0808 | 0.0808 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0374 | 0.0808 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0374 | 0.0808 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.99 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.