Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | kinesin-5 | 0.0109 | 0.0424 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0109 | 0.0424 | 0.31 |
Brugia malayi | Kinesin motor domain containing protein | 0.0109 | 0.0424 | 0.31 |
Plasmodium vivax | kinesin-5 | 0.0109 | 0.0424 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0109 | 0.0424 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0728 | 0.857 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1366 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.1366 | 0.1366 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1366 | 1 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.1366 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0837 | 1 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0109 | 0.0424 | 0.0494 |
Entamoeba histolytica | kinesin, putative | 0.0109 | 0.0424 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0109 | 0.0424 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.1366 | 0.1366 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.1366 | 0.1366 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.