Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.4886 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.5608 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0075 | 0.5608 | 0.4886 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0123 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Brugia malayi | Histone deacetylase family protein | 0.0058 | 0.4009 | 0.4009 |
Echinococcus granulosus | histone deacetylase 3 | 0.0075 | 0.5608 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1218 | 0.1218 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0075 | 0.5608 | 0.4886 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus multilocularis | histone deacetylase | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0058 | 0.4009 | 0.4009 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0058 | 0.4009 | 0.3025 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0064 | 0.4578 | 0.3687 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0123 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus granulosus | histone deacetylase 6 | 0.0064 | 0.4578 | 0.3687 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0123 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0058 | 0.4009 | 0.4009 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0075 | 0.5608 | 0.4886 |
Plasmodium vivax | histone deacetylase, putative | 0.0058 | 0.4009 | 0.3025 |
Echinococcus granulosus | histone deacetylase | 0.0058 | 0.4009 | 0.3025 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.003 | 0.1412 | 0.1412 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0123 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus granulosus | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus multilocularis | 0.0123 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1787 | 0.1787 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1412 | 0.1412 |
Trypanosoma brucei | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.003 | 0.1412 | 0.1412 |
Trypanosoma brucei | histone deacetylase 2 | 0.003 | 0.1412 | 0.1412 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.5608 | 0.4886 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0123 | 1 | 1 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0123 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.003 | 0.1412 | 0.1412 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0075 | 0.5608 | 0.5608 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.5608 | 0.4886 |
Mycobacterium ulcerans | hypothetical protein | 0.0054 | 0.3589 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0064 | 0.4578 | 0.3687 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma brucei | histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0054 | 0.3589 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0058 | 0.4009 | 0.4009 |
Trypanosoma brucei | histone deacetylase 4 | 0.0058 | 0.4009 | 0.4009 |
Trypanosoma brucei | histone deacetylase 3 | 0.0058 | 0.4009 | 0.4009 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.003 | 0.1412 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.0058 | 0.4009 | 0.3025 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.5608 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Plasmodium falciparum | histone deacetylase 1 | 0.0075 | 0.5608 | 0.2668 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0075 | 0.5608 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5608 | 0.5608 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0058 | 0.4009 | 0.3025 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0075 | 0.5608 | 0.5608 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0058 | 0.4009 | 0.3025 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Brugia malayi | Histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.003 | 0.1412 | 0.1412 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0075 | 0.5608 | 0.4886 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (ADMET) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (ADMET) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.