Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone deacetylase 7A | 0.0058 | 0.4009 | 0.4009 |
Trypanosoma brucei | histone deacetylase 3 | 0.0058 | 0.4009 | 0.4009 |
Plasmodium vivax | histone deacetylase, putative | 0.0058 | 0.4009 | 0.3025 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0054 | 0.3589 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0075 | 0.5608 | 0.2668 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1412 | 0.1412 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus granulosus | histone deacetylase 3 | 0.0075 | 0.5608 | 0.4886 |
Echinococcus multilocularis | histone deacetylase | 0.0058 | 0.4009 | 0.3025 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0058 | 0.4009 | 0.4009 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0058 | 0.4009 | 0.3025 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0123 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.5608 | 0.5608 |
Echinococcus granulosus | histone deacetylase 1 | 0.0075 | 0.5608 | 0.4886 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0058 | 0.4009 | 0.4009 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.4886 |
Leishmania major | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0123 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.003 | 0.1412 | 0.5 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0064 | 0.4578 | 0.3687 |
Trypanosoma brucei | histone deacetylase 2 | 0.003 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | histone deacetylase | 0.0058 | 0.4009 | 0.4009 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0064 | 0.4578 | 0.3687 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0075 | 0.5608 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1787 | 0.1787 |
Echinococcus granulosus | histone deacetylase 7 | 0.0058 | 0.4009 | 0.3025 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0075 | 0.5608 | 0.5608 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0064 | 0.4578 | 0.3687 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0123 | 1 | 1 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.5608 | 0.4886 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0075 | 0.5608 | 0.4886 |
Trypanosoma brucei | histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Trypanosoma brucei | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus granulosus | histone deacetylase | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.003 | 0.1412 | 0.1412 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.5608 | 0.4886 |
Brugia malayi | Histone deacetylase family protein | 0.0058 | 0.4009 | 0.4009 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0058 | 0.4009 | 0.3025 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0123 | 1 | 1 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus multilocularis | 0.0123 | 1 | 1 | |
Leishmania major | histone deacetylase, putative | 0.0058 | 0.4009 | 0.4009 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Trypanosoma cruzi | histone deacetylase, putative | 0.003 | 0.1412 | 0.1412 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0075 | 0.5608 | 0.5608 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0123 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0058 | 0.4009 | 0.3025 |
Brugia malayi | histone deacetylase 11 | 0.003 | 0.1412 | 0.1412 |
Mycobacterium ulcerans | hypothetical protein | 0.0054 | 0.3589 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0075 | 0.5608 | 0.5608 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0123 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.5608 | 0.5608 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0058 | 0.4009 | 0.3025 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0123 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.003 | 0.1412 | 0.1412 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.5608 | 0.5608 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1218 | 0.1218 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0075 | 0.5608 | 0.4886 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0075 | 0.5608 | 0.4886 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0123 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (ADMET) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (ADMET) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.