Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0263 | 0.0041 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0378 | 0.0864 | 0.0827 |
Echinococcus multilocularis | tumor protein p63 | 0.0378 | 0.0864 | 0.0827 |
Mycobacterium tuberculosis | Conserved protein | 0.0263 | 0.0041 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0263 | 0.0041 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0263 | 0.0041 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0772 | 0.3687 | 0.3661 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.1653 | 1 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0263 | 0.0041 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0772 | 0.3687 | 0.3661 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.1653 | 1 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0263 | 0.0041 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.1653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1653 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0263 | 0.0041 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0263 | 0.0041 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0263 | 0.0041 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0263 | 0.0041 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.1653 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0263 | 0.0041 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0772 | 0.3687 | 0.3661 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0263 | 0.0041 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0263 | 0.0041 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0263 | 0.0041 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0263 | 0.0041 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (binding) | = 43 % | Compound was evaluated for its inhibitory activity against cathepsin B at 100 microM concentration of substrate | ChEMBL. | 11128641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.