Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.8 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 440 aa | 30.0 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D2 receptor | 444 aa | 433 aa | 21.2 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1995 | 0.5 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.1995 | 0.5 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.1995 | 0.5 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.1995 | 0.5 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.1995 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1995 | 0.5 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.1995 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1995 | 0.5 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.1995 | 0.5 | 0.5 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.1995 | 0.5 | 0.5 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.1995 | 0.5 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.1995 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9.8 nM | Inhibition of [3H]-quinpirole binding to rat striatal membrane Dopamine receptor D2 without GTP and sodium | ChEMBL. | 10498215 |
Ki (binding) | = 9.8 nM | Inhibition of [3H]-quinpirole binding to rat striatal membrane Dopamine receptor D2 without GTP and sodium | ChEMBL. | 10498215 |
Ki (binding) | = 51.6 nM | Inhibition of [3H]-spiperone binding to human Dopamine receptor D4.4 expressed in CHO cell membranes | ChEMBL. | 10498215 |
Ki (binding) | = 51.6 nM | Inhibition of [3H]-spiperone binding to human Dopamine receptor D4.4 expressed in CHO cell membranes | ChEMBL. | 10498215 |
Ki (binding) | = 67.2 nM | Inhibition of [3H]-spiperone binding to human Dopamine receptor D3 in CHO cell membranes | ChEMBL. | 10498215 |
Ki (binding) | = 67.2 nM | Inhibition of [3H]-spiperone binding to human Dopamine receptor D3 in CHO cell membranes | ChEMBL. | 10498215 |
Ki (binding) | = 85.6 nM | Inihibition of [3H]-spiperone binding to human Dopamine receptor D2 in CHO cell membranes | ChEMBL. | 10498215 |
Ki (binding) | = 85.6 nM | Inihibition of [3H]-spiperone binding to human Dopamine receptor D2 in CHO cell membranes | ChEMBL. | 10498215 |
Ki (binding) | = 128 nM | Inhibtion of [3H]-spiperone binding to rat striatal membrane Dopamine receptor D2 low affinity without GTP and sodium | ChEMBL. | 10498215 |
Ki (binding) | = 128 nM | Inhibtion of [3H]-spiperone binding to rat striatal membrane Dopamine receptor D2 low affinity without GTP and sodium | ChEMBL. | 10498215 |
Ratio (binding) | = 13 | Relative binding affinity for low and hugh affinity type dopamine D2 receptors in rat striatal membranes | ChEMBL. | 10498215 |
Ratio (binding) | = 13 | Relative binding affinity for low and hugh affinity type dopamine D2 receptors in rat striatal membranes | ChEMBL. | 10498215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.