Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0642 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0642 | 1 | 1 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0642 | 1 | 1 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0642 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0642 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.1268 | 0.1268 |
Leishmania major | fatty acid elongase, putative | 0.0642 | 1 | 1 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.013 | 0.1268 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.013 | 0.1268 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.013 | 0.1268 | 0.5 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.013 | 0.1268 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.013 | 0.1268 | 0.5 |
Brugia malayi | fatty acid elongation protein 3 | 0.013 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.013 | 0.1268 | 0.1268 |
Brugia malayi | GNS1/SUR4 family protein | 0.013 | 0.1268 | 0.1268 |
Leishmania major | fatty acid elongase, putative | 0.0642 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0642 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.013 | 0.1268 | 0.1268 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.013 | 0.1268 | 1 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0642 | 1 | 1 |
Trypanosoma brucei | Fatty acid elongase | 0.0642 | 1 | 1 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0642 | 1 | 1 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.013 | 0.1268 | 0.1268 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0642 | 1 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.013 | 0.1268 | 0.1268 |
Leishmania major | fatty acid elongase, putative | 0.0642 | 1 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.013 | 0.1268 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.013 | 0.1268 | 0.1268 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.013 | 0.1268 | 1 |
Loa Loa (eye worm) | ELO-9 protein | 0.013 | 0.1268 | 0.1268 |
Brugia malayi | GNS1/SUR4 family protein | 0.0642 | 1 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.013 | 0.1268 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.013 | 0.1268 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.013 | 0.1268 | 0.5 |
Onchocerca volvulus | 0.013 | 0.1268 | 0.5 | |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.013 | 0.1268 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.013 | 0.1268 | 0.1268 |
Onchocerca volvulus | 0.013 | 0.1268 | 0.5 | |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0642 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.013 | 0.1268 | 0.1268 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0642 | 1 | 1 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.013 | 0.1268 | 0.1268 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0657 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.