Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0146 | 0.256 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0146 | 0.256 | 0.256 |
Onchocerca volvulus | 0.0114 | 0.127 | 0.5 | |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0146 | 0.256 | 0.256 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0082 | 0 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0255 | 0.6957 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 1 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0146 | 0.256 | 0.256 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0255 | 0.6957 | 0.6957 |
Schistosoma mansoni | acetolactate synthase | 0.0218 | 0.5462 | 0.3005 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0146 | 0.256 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.4618 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.4618 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.033 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0146 | 0.256 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0255 | 0.6957 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.4618 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.4618 | 0.2756 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0082 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0255 | 0.6957 | 0.5 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0255 | 0.6957 | 0.4347 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0082 | 0 | 0.5 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0255 | 0.6957 | 0.6957 |
Schistosoma mansoni | acetolactate synthase | 0.0218 | 0.5462 | 0.3005 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0082 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0255 | 0.6957 | 1 |
Loa Loa (eye worm) | glutaminase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0154 | 0.2902 | 0.0447 |
Mycobacterium ulcerans | hypothetical protein | 0.0255 | 0.6957 | 0.6957 |
Schistosoma mansoni | glutaminase | 0.033 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.4932 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.