Detailed view for MUL_1348

Basic information

TDR Targets ID: 953156
Mycobacterium ulcerans, acetolactate synthase large subunit IlvB
Source Database / ID:  KEGG  

pI: 5.8277 | Length (AA): 558 | MW (Da): 60092 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00205   Thiamine pyrophosphate enzyme, central domain
PF02775   Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02776   Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030976   thiamin pyrophosphate binding  
GO:0003824   catalytic activity  
GO:0000287   magnesium ion binding  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 558 2dji (A) 5 568 22.00 0 1 1.29802 -0.31
7 540 4rji (A) 18 553 33.00 0 1 1.40979 -0.61
185 329 4j1t (C) 277 447 16.00 0 0.93 0.350057 -0.78
189 256 3cf4 (G) 23 90 37.00 0.34 0.93 0.534664 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_152391)

Species Accession Gene Product
Mycobacterium ulcerans MUL_1348   acetolactate synthase large subunit IlvB
Mycobacterium ulcerans MUL_2433   acetolactate synthase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Lolium rigidum Acetolactate synthase 516 aa 28.8% 525 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0793 0.5661 0.5618
0.0076 0.3143 0.368
0.0253 0.2724 0.5621
0.0147 0.4442 0.4994
0.0125 0.2525 0
0.0204 0.368 0.368
0.0132 0.2525 0
0.0146 0.256 0.256
0.0506 0.5475 0.4994
0.0076 0.368 0.368
0.0221 0.5526 0.5511
0.013 0.2531 0.4994
0.0246 0.4994 0.4994
0.0457 0.3807 0.552
0.0704 0.562 0.4994
0.0327 0.5325 0.4994
0.0257 0.4798 0.4798
0.0316 0.5357 0.4994
0.0459 0.5438 0.4994
0.0355 0.3463 0.4994
0.0448 0.5521 0.5461
0.044 0.5446 0.4994
0.0662 0.5586 0.5546
0.0249 0.4994 0.4994
0.0249 0.4994 0.4994
0.0076 0.2525 0
0.0076 0.368 0.368
0.0249 0.4994 0.4994
0.0257 0.5253 0.4994
0.0514 0.5547 0.4994
0.0249 0.4994 0.4994
0.0186 0.5286 0.4994
0.0131 0.4535 0.368
0.0249 0.4994 0.4994
0.0131 0.3822 0.4798
0.0338 0.4844 0.4798
0.0076 0.2525 0
0.0282 0.2722 0.4994
0.0195 0.4798 0.4798
0.0131 0.4535 0.368
0.0133 0.4759 0.368
0.0123 0.4994 0.4994
0.0384 0.5581 0.5531
0.0797 0.5608 0.5574
0.0386 0.4264 0.4994
0.0267 0.2853 0.4994
0.0264 0.2525 0
0.0249 0.4994 0.4994
0.0249 0.4994 0.4994
0.047 0.5471 0.4994
0.0656 0.5586 0.5544
0.0462 0.5397 0.4994
0.0192 0.5014 0.4994
0.0076 0.2525 0
0.0076 0.368 0.368
0.0217 0.368 0.368
0.065 0.5582 0.5546
0.0249 0.4994 0.4994
0.0195 0.2689 0.5488
0.0319 0.3116 0.5596
0.0435 0.4994 0.4994
0.0645 0.5652 0.5652
0.0441 0.5511 0.4994
0.033 0.3914 0.5547
0.0076 0.2525 0
0.0134 0.4198 0.4994
0.0127 0.4752 0.368
0.0221 0.5526 0.5511
0.0386 0.4994 0.4994
0.0664 0.5588 0.5548
0.0317 0.368 0.368
0.0249 0.4994 0.4994
0.033 0.3914 0.5547
0.0138 0.4798 0.4798
0.0448 0.4994 0.4994
0.0576 0.5641 0.5541
0.0317 0.5487 0.541
0.0148 0.5468 0.5369
0.0191 0.5034 0.4994
0.0125 0.4798 0.4798
0.0257 0.5211 0.4994
0.0251 0.5452 0.556
0.0311 0.2525 0
0.0249 0.4994 0.4994
0.0126 0.4798 0.4798
0.0205 0.535 0.4994
0.0293 0.368 0.368
0.0188 0.4798 0.4798
0.0073 0.368 0.368
0.0122 0.4774 0.368
0.0076 0.2525 0
0.044 0.5446 0.4994
0.0251 0.5452 0.556
0.0282 0.2722 0.4994
0.0134 0.4798 0.4798
0.0132 0.4798 0.4798
0.0249 0.4994 0.4994
0.0841 0.5661 0.5618
0.0076 0.3143 0.368
0.0271 0.281 0.4994
0.013 0.2531 0.4994
0.0257 0.5211 0.4994
0.0317 0.5333 0.4994
0.0076 0.4677 0.368
0.033 0.3914 0.5547
0.0205 0.4506 0.4221
0.0134 0.307 0.368
0.0449 0.4858 0.5611
0.0076 0.4798 0.4798
0.0249 0.4994 0.4994
0.0325 0.3495 0.4994
0.0076 0.2864 0.4749
0.0249 0.4994 0.4994
0.0152 0.2525 0
0.0249 0.4994 0.4994
0.0689 0.5616 0.4994
0.0139 0.4994 0.4994
0.0261 0.2894 0.537
0.0249 0.4994 0.4994
0.0213 0.2567 0.368
0.0076 0.3611 0.5079
0.014 0.4798 0.4798
0.0249 0.4994 0.4994

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_1348 (Mycobacterium ulcerans), acetolactate synthase large subunit IlvB
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