Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | glycosyltransferase | 0.0371 | 0.3991 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0091 | 0.0373 | 0.0298 |
Echinococcus granulosus | alpha glucosidase | 0.0091 | 0.0373 | 0.0298 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.0373 | 0.0298 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1104 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0836 | 1 | 1 |
Mycobacterium tuberculosis | 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) | 0.0371 | 0.3991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1104 | 0.2767 |
Trichomonas vaginalis | amylase, putative | 0.0371 | 0.3991 | 0.3758 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0371 | 0.3991 | 0.3758 |
Schistosoma mansoni | starch branching enzyme II | 0.0371 | 0.3991 | 1 |
Loa Loa (eye worm) | alpha amylase | 0.0091 | 0.0373 | 0.0934 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0371 | 0.3991 | 1 |
Echinococcus multilocularis | trehalose 6 phosphate hydrolase | 0.0091 | 0.0373 | 0.0298 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0836 | 1 | 1 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0371 | 0.3991 | 1 |
Echinococcus multilocularis | alpha glucosidase | 0.0091 | 0.0373 | 0.0298 |
Schistosoma mansoni | alpha-amylase | 0.0091 | 0.0373 | 0.0298 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0744 | 0.8818 | 0.8772 |
Loa Loa (eye worm) | alpha amylase | 0.0091 | 0.0373 | 0.0934 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0371 | 0.3991 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1104 | 0.2022 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0371 | 0.3991 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1104 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.3991 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0091 | 0.0373 | 0.0298 |
Entamoeba histolytica | 1,4-alpha-glucan branching enzyme, putative | 0.0371 | 0.3991 | 0.3758 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0371 | 0.3991 | 1 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0371 | 0.3991 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0091 | 0.0373 | 0.0298 |
Mycobacterium ulcerans | glycogen branching protein | 0.0371 | 0.3991 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0836 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1104 | 0.2767 |
Entamoeba histolytica | 1,4-alpha-glucan branching enzyme, putative | 0.0371 | 0.3991 | 0.3758 |
Trichomonas vaginalis | amylase, putative | 0.0836 | 1 | 1 |
Echinococcus granulosus | trehalose 6 phosphate hydrolase | 0.0091 | 0.0373 | 0.0298 |
Trichomonas vaginalis | amylase, putative | 0.0836 | 1 | 1 |
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0371 | 0.3991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1755 | 0.4398 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0091 | 0.0373 | 0.5 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0198 | 0.1755 | 0.382 |
Schistosoma mansoni | alpha-amylase | 0.0091 | 0.0373 | 0.0298 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0836 | 1 | 1 |
Entamoeba histolytica | alpha-amylase family protein | 0.0836 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.4467 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.