Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0075 | 0.222 | 0.2389 |
Echinococcus granulosus | geminin | 0.0174 | 0.6011 | 0.6432 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.1027 | 0.1104 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.6011 | 0.8062 |
Brugia malayi | Pax transcription factor protein 2 | 0.0247 | 0.8806 | 0.9474 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0351 | 0.0377 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1027 | 0.1274 |
Brugia malayi | bZIP transcription factor family protein | 0.0259 | 0.9295 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0247 | 0.8806 | 0.9758 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1027 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0259 | 0.9295 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0091 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1027 | 0.1048 |
Echinococcus multilocularis | jun protein | 0.0259 | 0.9295 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.222 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.1027 | 0.1048 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1667 | 0.1765 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0938 | 0.1153 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.1027 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.1027 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1027 | 0.1274 |
Echinococcus granulosus | jun protein | 0.0259 | 0.9295 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1027 | 0.1048 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.1027 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.4046 | 0.4429 |
Schistosoma mansoni | hypothetical protein | 0.0211 | 0.7434 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.222 | 0.2313 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1027 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.1027 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0351 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.4046 | 0.4353 |
Brugia malayi | beta-lactamase | 0.0043 | 0.1027 | 0.1104 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0938 | 0.1009 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.1027 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1667 | 0.1794 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.1027 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.222 | 0.29 |
Onchocerca volvulus | 0.0247 | 0.8806 | 1 | |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.1027 | 0.5 |
Echinococcus multilocularis | geminin | 0.0174 | 0.6011 | 0.6432 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.1027 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.1027 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1027 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1027 | 0.1104 |
Brugia malayi | hypothetical protein | 0.0204 | 0.7162 | 0.7705 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.9022 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.222 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1027 | 0.1048 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.222 | 0.2313 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.222 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1027 | 0.1048 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1027 | 0.1104 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1027 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.1027 | 0.1017 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0259 | 0.9295 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.1027 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.1027 | 0.1048 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.4046 | 0.4429 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1027 | 0.1048 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1027 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.222 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0211 | 0.7434 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.1027 | 0.1017 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1027 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0351 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0351 | 0.0291 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.1027 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1667 | 0.1794 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.1027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1027 | 0.1048 |
Onchocerca volvulus | 0.0204 | 0.7162 | 0.7886 | |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.6011 | 0.8062 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.222 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0091 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0938 | 0.0948 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1667 | 0.1765 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.