Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | AAA family ATPase | 0.0705 | 0.5718 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0705 | 0.5718 | 0.5718 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.1118 | 0.9451 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.1118 | 0.9451 | 1 |
Mycobacterium ulcerans | ATPase | 0.0705 | 0.5718 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.1118 | 0.9451 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1118 | 0.9451 | 0.9451 |
Brugia malayi | vesicle-fusing ATPase | 0.0691 | 0.559 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1178 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1178 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.1118 | 0.9451 | 0.5 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1178 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0487 | 0.3746 | 0.3746 |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 0.559 | 1 |
Brugia malayi | valosin containing protein | 0.0691 | 0.559 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1178 | 1 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.1118 | 0.9451 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.1118 | 0.9451 | 0.5 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0705 | 0.5718 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0487 | 0.3746 | 0.3746 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0691 | 0.559 | 1 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0705 | 0.5718 | 0.5718 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1178 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.185 | 0.3235 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.1118 | 0.9451 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.