Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0896 | 0.4742 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.142 | 0.9326 | 0.5 |
Brugia malayi | vesicle-fusing ATPase | 0.0878 | 0.4584 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1497 | 1 | 1 |
Giardia lamblia | AAA family ATPase | 0.0896 | 0.4742 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.142 | 0.9326 | 0.5 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1497 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0878 | 0.4584 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0619 | 0.232 | 0.1938 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1497 | 1 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.142 | 0.9326 | 0.5 |
Brugia malayi | valosin containing protein | 0.0878 | 0.4584 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1497 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.142 | 0.9326 | 0.9122 |
Entamoeba histolytica | cdc48-like protein, putative | 0.142 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1497 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0896 | 0.4742 | 0.0000097958 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0878 | 0.4584 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.142 | 0.9326 | 1 |
Mycobacterium ulcerans | ATPase | 0.0896 | 0.4742 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.142 | 0.9326 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.142 | 0.9326 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.