Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 1 | 1 |
Plasmodium vivax | serine C-palmitoyltransferase, putative | 0.0026 | 0 | 0.5 |
Leishmania major | serine palmitoyltransferase-like protein | 0.0041 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.5784 | 0.5 | |
Trypanosoma cruzi | serine-palmitoyl-CoA transferase, putative | 0.0041 | 1 | 1 |
Toxoplasma gondii | 8-amino-7-oxononanoate synthase | 0.0026 | 0 | 0.5 |
Giardia lamblia | Serine palmitoyltransferase 1 | 0.0041 | 1 | 1 |
Chlamydia trachomatis | 8-amino-7-oxononanoate synthase | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | serine palmitoyltransferase subunit | 0.0035 | 0.5784 | 0.5784 |
Echinococcus multilocularis | serine palmitoyltransferase, long chain base | 0.0041 | 1 | 1 |
Schistosoma mansoni | serine palmitoyltransferase 1 | 0.0041 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.5784 | 0.5784 |
Trichomonas vaginalis | 2-amino-3-ketobutyrate coenzyme A ligase, putative | 0.0041 | 1 | 1 |
Echinococcus granulosus | serine palmitoyltransferase long chain base | 0.0041 | 1 | 1 |
Toxoplasma gondii | glycine C-acetyltransferase, putative | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | serine palmitoyltransferase, putative | 0.0041 | 1 | 1 |
Entamoeba histolytica | serine palmitoyltransferase, putative | 0.0026 | 0 | 0.5 |
Entamoeba histolytica | serine palmitoyltransferase, putative | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | serine-palmitoyl-CoA transferase, putative | 0.0041 | 1 | 1 |
Plasmodium falciparum | serine C-palmitoyltransferase, putative | 0.0026 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.