pI: 7.7528 |
Length (AA): 48 |
MW (Da): 4973 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 48 | 1fc4 (A) | 237 | 285 | 40.00 | 0.08 | 0.08 | 1.1857 | 1.95 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128841)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G36480 | serine palmitoyltransferase |
Brugia malayi | Bm1_28505 | hypothetical protein |
Brugia malayi | Bm1_01170 | hypothetical protein |
Candida albicans | CaO19.6438 | putative serine palmitoyltransferase component |
Candida albicans | CaO19.13796 | putative serine palmitoyltransferase component |
Caenorhabditis elegans | CELE_C23H3.4 | Protein SPTL-1, isoform A |
Dictyostelium discoideum | DDB_G0268056 | serine C-palmitoyltransferase subunit |
Drosophila melanogaster | Dmel_CG4016 | Serine palmitoyltransferase subunit I |
Echinococcus granulosus | EgrG_000146100 | serine palmitoyltransferase long chain base |
Echinococcus multilocularis | EmuJ_000138200 | serine palmitoyltransferase subunit |
Echinococcus multilocularis | EmuJ_000146100 | serine palmitoyltransferase, long chain base |
Giardia lamblia | GL50803_23015 | Serine palmitoyltransferase 1 |
Homo sapiens | ENSG00000090054 | serine palmitoyltransferase, long chain base subunit 1 |
Leishmania braziliensis | LbrM.20.3330 | serine palmitoyltransferase-like protein |
Leishmania donovani | LdBPK_343530.1 | serine palmitoyltransferase-like protein |
Leishmania infantum | LinJ.34.3530 | serine palmitoyltransferase-like protein |
Leishmania major | LmjF.34.3740 | serine palmitoyltransferase-like protein |
Leishmania mexicana | LmxM.33.3740 | serine palmitoyltransferase-like protein |
Loa Loa (eye worm) | LOAG_12237 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11347 | hypothetical protein |
Mus musculus | ENSMUSG00000021468 | serine palmitoyltransferase, long chain base subunit 1 |
Oryza sativa | 4331075 | Os02g0806900 |
Oryza sativa | 4348231 | Os10g0189600 |
Oryza sativa | 4332274 | Os03g0252800 |
Onchocerca volvulus | OVOC11372 |
|
Saccharomyces cerevisiae | YMR296C | serine C-palmitoyltransferase LCB1 |
Schistosoma japonicum | Sjp_0029360 | ko:K00654 serine palmitoyltransferase [EC2.3.1.50], putative |
Schistosoma mansoni | Smp_028080 | serine palmitoyltransferase 1 |
Schmidtea mediterranea | mk4.004471.01 | Serine palmitoyltransferase 1 |
Schmidtea mediterranea | mk4.026684.00 | Serine palmitoyltransferase 1 |
Schmidtea mediterranea | mk4.015615.00 | Serine palmitoyltransferase 1 |
Schmidtea mediterranea | mk4.010920.02 | |
Trypanosoma brucei gambiense | Tbg972.4.850 | serine-palmitoyl-CoA transferase, putative |
Trypanosoma brucei | Tb927.4.1020 | serine-palmitoyl-CoA transferase, putative |
Trypanosoma congolense | TcIL3000_4_630 | serine-palmitoyl-CoA transferase, putative |
Trypanosoma cruzi | TcCLB.506405.50 | serine-palmitoyl-CoA transferase, putative |
Trichomonas vaginalis | TVAG_130270 | serine palmitoyltransferase, putative |
Trichomonas vaginalis | TVAG_076510 | 2-amino-3-ketobutyrate coenzyme A ligase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.1020 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1020 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1020 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.1020 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C23H3.4 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_C23H3.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C23H3.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C23H3.4 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C23H3.4 | Caenorhabditis elegans | slow growth | wormbase |
YMR296C | Saccharomyces cerevisiae | inviable | yeastgenome |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | serine palmitoyltransferase, long chain base subunit 1 | Compounds | References |