Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | coup transcription factor | 0.007 | 0.0236 | 0.0316 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.007 | 0.0236 | 0.0191 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.007 | 0.0236 | 0.0316 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0056 | 0.0055 | 0.5 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0235 | 0.2329 | 0.24 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.007 | 0.0236 | 0.0316 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.007 | 0.0236 | 0.0248 |
Schistosoma mansoni | nuclear hormone receptor | 0.007 | 0.0236 | 0.0316 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.007 | 0.0236 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0236 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9109 | 0.9559 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0236 | 0.0248 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.007 | 0.0236 | 0.0182 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0236 | 0.0248 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.007 | 0.0236 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.2329 | 0.2444 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.007 | 0.0236 | 0.0316 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.007 | 0.0236 | 0.0316 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0056 | 0.0055 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.007 | 0.0236 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0236 | 0.0248 |
Schistosoma mansoni | thyroid hormone receptor | 0.007 | 0.0236 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0236 | 0.0248 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0056 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0236 | 0.0248 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.007 | 0.0236 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.007 | 0.0236 | 0.0191 |
Schistosoma mansoni | thyroid hormone receptor | 0.007 | 0.0236 | 0.0316 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.007 | 0.0236 | 0.0316 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0056 | 0.0055 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.007 | 0.0236 | 0.0248 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.007 | 0.0236 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0055 | 0.0058 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.007 | 0.0236 | 0.0248 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.007 | 0.0236 | 0.0248 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.007 | 0.0236 | 0.0316 |
Trichomonas vaginalis | cdc25c, putative | 0.0056 | 0.0055 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.007 | 0.0236 | 0.0191 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.047 | 0.5306 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0802 | 0.9529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0236 | 0.0248 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.007 | 0.0236 | 0.0344 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.007 | 0.0236 | 0.0316 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.007 | 0.0236 | 0.0191 |
Brugia malayi | ecdysteroid receptor | 0.007 | 0.0236 | 0.0191 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.007 | 0.0236 | 0.0316 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.007 | 0.0236 | 0.0344 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.007 | 0.0236 | 0.0248 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.007 | 0.0236 | 0.0191 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.007 | 0.0236 | 0.0344 |
Trichomonas vaginalis | cdc25b, putative | 0.0056 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0055 | 0.0058 |
Trichomonas vaginalis | cdc25b, putative | 0.0056 | 0.0055 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.007 | 0.0236 | 0.0344 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0507 | 0.5777 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.007 | 0.0236 | 0.0191 |
Onchocerca volvulus | Bile acid receptor homolog | 0.007 | 0.0236 | 0.0182 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.007 | 0.0236 | 0.0316 |
Brugia malayi | nuclear hormone receptor | 0.0802 | 0.9529 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.007 | 0.0236 | 0.0316 |
Echinococcus multilocularis | FTZ F1 alpha | 0.007 | 0.0236 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0236 | 0.0248 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0507 | 0.5777 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.007 | 0.0236 | 0.0316 |
Onchocerca volvulus | 0.007 | 0.0236 | 0.0182 | |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.007 | 0.0236 | 0.0191 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | steroid hormone receptor | 0.007 | 0.0236 | 0.0248 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.2071 | 0.2174 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0056 | 0.0055 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.007 | 0.0236 | 0.0344 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.007 | 0.0236 | 0.0191 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.007 | 0.0236 | 0.0248 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0056 | 0.0055 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.007 | 0.0236 | 0.0344 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0056 | 0.0055 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.007 | 0.0236 | 0.0316 |
Echinococcus granulosus | FTZ F1 alpha | 0.007 | 0.0236 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.4485 | 0.4706 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0056 | 0.0055 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.007 | 0.0236 | 0.0344 |
Brugia malayi | steroid hormone receptor | 0.007 | 0.0236 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.007 | 0.0236 | 0.0191 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.007 | 0.0236 | 0.0316 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha; Not active | ChEMBL. | 8709094 |
EC50 (functional) | 0 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
EC50 (functional) | 0 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma; Not active | ChEMBL. | 8709094 |
EC50 (functional) | = 0.34 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
EC50 (functional) | = 0.34 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
EC50 (functional) | = 2.2 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
EC50 (functional) | = 2.2 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
EC50 (functional) | = 4 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
EC50 (functional) | = 4 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
EC50 (functional) | = 16 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
EC50 (functional) | = 16 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
EC50 (functional) | = 24 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
EC50 (functional) | = 24 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
EC50 (functional) | = 65 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
EC50 (functional) | = 65 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
EC50 (functional) | = 77 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma | ChEMBL. | 8709094 |
EC50 (functional) | = 77 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma | ChEMBL. | 8709094 |
EC50 (functional) | = 87 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
EC50 (functional) | = 87 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
EC50 (functional) | = 134 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha | ChEMBL. | 8709094 |
EC50 (functional) | = 134 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha | ChEMBL. | 8709094 |
Efficacy (functional) | = 27 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
Efficacy (functional) | = 27 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
Efficacy (functional) | = 31 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
Efficacy (functional) | = 31 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
Efficacy (functional) | = 39 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
Efficacy (functional) | = 39 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
Efficacy (functional) | = 40 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoid X receptor RXR gamma | ChEMBL. | 8709094 |
Efficacy (functional) | = 40 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
Efficacy (functional) | = 40 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoid X receptor RXR gamma | ChEMBL. | 8709094 |
Efficacy (functional) | = 40 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
Efficacy (functional) | = 45 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
Efficacy (functional) | = 45 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
Efficacy (functional) | = 48 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
Efficacy (functional) | = 48 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
Efficacy (functional) | = 56 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoid X receptor RXR alpha | ChEMBL. | 8709094 |
Efficacy (functional) | = 56 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoid X receptor RXR alpha | ChEMBL. | 8709094 |
Efficacy (functional) | = 58 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
Efficacy (functional) | = 58 % | Percent transcriptional activation relative to ATRA in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 0.7 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
Ki (binding) | = 0.7 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
Ki (binding) | = 1.1 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
Ki (binding) | = 1.1 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
Ki (binding) | = 1.9 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 1.9 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 4.6 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR alpha | ChEMBL. | 8709094 |
Ki (binding) | = 4.6 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR alpha | ChEMBL. | 8709094 |
Ki (binding) | = 9.3 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 9.3 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 10.2 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
Ki (binding) | = 10.2 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
Ki (binding) | = 63.5 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
Ki (binding) | = 63.5 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR alpha | ChEMBL. | 8709094 |
Ki (binding) | = 90 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
Ki (binding) | = 90 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR beta | ChEMBL. | 8709094 |
Ki (binding) | = 124 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 124 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 223 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR alpha | ChEMBL. | 8709094 |
Ki (binding) | = 223 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR alpha | ChEMBL. | 8709094 |
Ki (binding) | = 320 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 320 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR gamma | ChEMBL. | 8709094 |
Ki (binding) | = 560 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
Ki (binding) | = 560 nM | Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR beta | ChEMBL. | 8709094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.