Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0663 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0112 | 0.1534 | 0.1534 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0112 | 0.1534 | 0.1534 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0112 | 0.1534 | 0.1534 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0112 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1534 | 0.1534 |
Brugia malayi | Carboxylesterase family protein | 0.0112 | 0.1534 | 0.1534 |
Brugia malayi | hypothetical protein | 0.0112 | 0.1534 | 0.1534 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0112 | 0.1534 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1534 | 0.1534 |
Brugia malayi | Carboxylesterase family protein | 0.0112 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0112 | 0.1534 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0663 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0663 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0112 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | carboxylesterase | 0.0663 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0112 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0112 | 0.1534 | 1 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0112 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0112 | 0.1534 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0112 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | carboxylesterase | 0.0112 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0112 | 0.1534 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0112 | 0.1534 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0663 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1534 | 0.1534 |
Brugia malayi | Carboxylesterase family protein | 0.0112 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0663 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0112 | 0.1534 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0112 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0663 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0112 | 0.1534 | 0.1534 |
Brugia malayi | Carboxylesterase family protein | 0.0112 | 0.1534 | 0.1534 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0112 | 0.1534 | 0.1534 |
Echinococcus multilocularis | acetylcholinesterase | 0.0663 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1534 | 0.1534 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0112 | 0.1534 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0112 | 0.1534 | 0.1534 |
Echinococcus multilocularis | acetylcholinesterase | 0.0663 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1534 | 0.1534 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0663 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0663 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0112 | 0.1534 | 0.1534 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0112 | 0.1534 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0112 | 0.1534 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0112 | 0.1534 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0112 | 0.1534 | 0.1534 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0112 | 0.1534 | 0.1534 |
Echinococcus granulosus | acetylcholinesterase | 0.0663 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0112 | 0.1534 | 0.1534 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.