Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0342 | 0.547 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0183 | 0.2417 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0342 | 0.547 | 0.5436 |
Onchocerca volvulus | 0.0579 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0342 | 0.547 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0183 | 0.2417 | 0.236 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0183 | 0.2417 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0268 | 0.4054 | 0.2563 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0183 | 0.2417 | 0.5 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0126 | 0.134 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0161 | 0.2006 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0183 | 0.2417 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Echinococcus granulosus | ectonucleotide | 0.0226 | 0.3247 | 0.3584 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0268 | 0.4054 | 0.2563 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0161 | 0.2006 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.3247 | 0.3584 |
Onchocerca volvulus | 0.0268 | 0.4054 | 0.2159 | |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0268 | 0.4054 | 0.2563 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0342 | 0.547 | 0.5436 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0579 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.3247 | 0.3584 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Schistosoma mansoni | hypothetical protein | 0.0579 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0226 | 0.3247 | 0.3584 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0161 | 0.2006 | 0.1945 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0268 | 0.4054 | 0.401 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0183 | 0.2417 | 0.5 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0183 | 0.2417 | 0.236 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.3247 | 0.3196 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Trypanosoma brucei | endonuclease G, putative | 0.0161 | 0.2006 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0183 | 0.2417 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0342 | 0.547 | 0.4333 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0161 | 0.2006 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0268 | 0.4054 | 0.2563 |
Trypanosoma brucei | endonuclease G, putative | 0.0161 | 0.2006 | 1 |
Leishmania major | endonuclease G, putative | 0.0161 | 0.2006 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0183 | 0.2417 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0183 | 0.2417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.4054 | 0.401 |
Trypanosoma cruzi | endonuclease G, putative | 0.0161 | 0.2006 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0183 | 0.2417 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0161 | 0.2006 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.4054 | 0.401 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0183 | 0.2417 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Onchocerca volvulus | 0.0268 | 0.4054 | 0.2159 | |
Trypanosoma brucei | endonuclease G, putative | 0.0161 | 0.2006 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0268 | 0.4054 | 0.5914 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.4054 | 0.401 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0161 | 0.2006 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.