Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0735 | 0.9686 | 0.9597 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0735 | 0.9686 | 0.9686 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0759 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.0555 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.2599 | 0.2165 |
Giardia lamblia | Kinase, TTK | 0.0759 | 1 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0735 | 0.9686 | 0.9667 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.0555 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0759 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2599 | 0.0507 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0555 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.2139 | 0.1677 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0759 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0759 | 1 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0759 | 1 | 0.5 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0759 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2599 | 0.2599 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.0498 | 0.5 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0735 | 0.9686 | 0.9597 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0759 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.0498 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.2204 | 0.2204 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2599 | 0.2599 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0735 | 0.9686 | 0.9597 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1636 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.2512 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 67.0158 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.