Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | X-box binding protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Mus musculus | DNA-damage inducible transcript 3 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0348 | 0.3312 | 0.3312 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0104 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0104 | 0.0104 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1026 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0104 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0323 | 0.3061 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1898 | 0.1898 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0104 | 0.5 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.1026 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0104 | 0.0104 |
Echinococcus granulosus | X box binding protein 1 | 0.0348 | 0.3312 | 0.3312 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0104 | 0.5 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.1026 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0104 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0323 | 0.3061 | 0.3061 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0323 | 0.3061 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0323 | 0.3061 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0104 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0104 | 0.0104 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0104 | 0.0104 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0104 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0104 | 0.0104 |
Echinococcus granulosus | geminin | 0.0205 | 0.1898 | 0.1898 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0104 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0323 | 0.3061 | 0.3061 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0104 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1898 | 0.1898 |
Echinococcus multilocularis | X box binding protein 1 | 0.0348 | 0.3312 | 0.3312 |
Brugia malayi | Protein kinase domain containing protein | 0.0323 | 0.3061 | 0.3061 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0104 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0104 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0323 | 0.3061 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0104 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1898 | 0.1898 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0323 | 0.3061 | 0.3061 |
Loa Loa (eye worm) | TTK protein kinase | 0.0323 | 0.3061 | 0.3061 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.1026 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.22 uM | PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] | ChEMBL. | No reference |
IC50 (functional) | > 9.56 uM | PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] | ChEMBL. | No reference |
Potency (functional) | 0.0028 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7308 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.5849 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 2.9362 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.