Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.3161 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0141 | 0.3765 | 0.3765 |
Schistosoma mansoni | thyroid hormone receptor | 0.0141 | 0.3765 | 0.3765 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0472 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0472 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0472 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0472 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0472 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0472 | 0.0472 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0472 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.3161 | 0.3161 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0472 | 0.1254 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0472 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0025 | 0.0178 | 0.3765 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.0178 | 0.3765 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0472 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0472 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.6275 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0472 | 0.5 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0472 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0472 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0472 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0472 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0472 | 0.0472 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0472 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0472 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0472 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0141 | 0.3765 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0472 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0472 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0472 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0472 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0472 | 0.1494 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0472 | 1 |
Onchocerca volvulus | 0.0035 | 0.0472 | 1 | |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.3161 | 0.8394 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0472 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0472 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0472 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0472 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0472 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0472 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0472 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0472 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12 nM | Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation counting | ChEMBL. | 21186123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.