Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0054 | 0.1034 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0054 | 0.1034 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1034 | 0.086 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1034 | 0.2553 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Mycobacterium ulcerans | oxidoreductase | 0.0038 | 0.0419 | 0.5 |
Echinococcus granulosus | cathepsin L | 0.0032 | 0.019 | 0.019 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.0419 | 0.0234 |
Giardia lamblia | Cathepsin B precursor | 0.0102 | 0.2826 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0039 | 0.0458 | 0.0274 |
Leishmania major | cysteine peptidase A (CPA) | 0.0054 | 0.1034 | 0.2553 |
Echinococcus multilocularis | cysteine protease | 0.0054 | 0.1034 | 0.1034 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Brugia malayi | Cathepsin L-like precursor | 0.0039 | 0.0458 | 0.0274 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1034 | 0.086 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0054 | 0.1034 | 0.1034 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Echinococcus granulosus | cathepsin l1 | 0.0039 | 0.0458 | 0.0458 |
Giardia lamblia | Cathepsin B precursor | 0.0102 | 0.2826 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Trypanosoma brucei | prostaglandin f synthase | 0.0038 | 0.0419 | 0.087 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0292 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Echinococcus multilocularis | cathepsin b | 0.0292 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1034 | 0.2553 |
Plasmodium vivax | vivapain-2 | 0.0054 | 0.1034 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0292 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.0419 | 0.0419 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0032 | 0.019 | 0.019 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0102 | 0.2826 | 0.2513 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0039 | 0.0458 | 0.1018 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0038 | 0.0419 | 0.087 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Loa Loa (eye worm) | fibroinase | 0.0054 | 0.1034 | 0.0641 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0054 | 0.1034 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0039 | 0.0458 | 0.0274 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Onchocerca volvulus | Cathepsin L homolog | 0.0054 | 0.1034 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0054 | 0.1034 | 0.1034 |
Giardia lamblia | Cathepsin B precursor | 0.0102 | 0.2826 | 1 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1034 | 0.2553 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0054 | 0.1034 | 0.086 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0054 | 0.1034 | 0.0641 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.0419 | 0.0419 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1034 | 0.2553 |
Echinococcus multilocularis | cathepsin L | 0.0032 | 0.019 | 0.019 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.0419 | 0.0234 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0458 | 0.0041 |
Onchocerca volvulus | 0.0054 | 0.1034 | 1 | |
Echinococcus granulosus | cysteine protease | 0.0032 | 0.019 | 0.019 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0102 | 0.2826 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Onchocerca volvulus | 0.0054 | 0.1034 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0054 | 0.1034 | 0.1034 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1034 | 0.2553 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0054 | 0.1034 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1034 | 0.086 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.0419 | 0.0419 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1034 | 0.086 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0054 | 0.1034 | 0.0641 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0054 | 0.1034 | 0.1034 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1034 | 0.086 |
Echinococcus granulosus | cathepsin l1 | 0.0054 | 0.1034 | 0.1034 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Brugia malayi | cathepsin L-like precursor | 0.0039 | 0.0458 | 0.0274 |
Onchocerca volvulus | 0.0039 | 0.0458 | 0.0637 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0038 | 0.0419 | 0.0234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0039 | 0.0458 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Onchocerca volvulus | 0.0054 | 0.1034 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1034 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trypanosoma cruzi | aldo-keto reductase | 0.0038 | 0.0419 | 0.0234 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1034 | 0.2553 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0054 | 0.1034 | 0.086 |
Onchocerca volvulus | 0.0054 | 0.1034 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0054 | 0.1034 | 0.1034 |
Onchocerca volvulus | 0.0054 | 0.1034 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Loa Loa (eye worm) | cysteine protease | 0.0054 | 0.1034 | 0.0641 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0054 | 0.1034 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0102 | 0.2826 | 0.2688 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.0419 | 0.0234 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Loa Loa (eye worm) | ctsf protein | 0.0054 | 0.1034 | 0.0641 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1034 | 0.0641 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0292 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0038 | 0.0419 | 0.087 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.0419 | 0.0234 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0054 | 0.1034 | 0.086 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0292 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0054 | 0.1034 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Echinococcus granulosus | cathepsin b | 0.0292 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.0419 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0038 | 0.0419 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0292 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0039 | 0.0458 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0054 | 0.1034 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Toxoplasma gondii | cathepsin CPL | 0.0054 | 0.1034 | 0.2553 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0054 | 0.1034 | 0.1034 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1034 | 0.086 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Entamoeba histolytica | cysteine protease, putative | 0.0054 | 0.1034 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0054 | 0.1034 | 1 |
Echinococcus granulosus | cathepsin b | 0.0292 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0038 | 0.0419 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.0419 | 0.0419 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.0419 | 0.2718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Toxoplasma gondii | cathepsin B | 0.0102 | 0.2826 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.0419 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.0419 | 0.2718 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1034 | 0.2553 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0102 | 0.2826 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0039 | 0.0458 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0458 | 0.0041 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.0419 | 0.2718 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0054 | 0.1034 | 1 |
Onchocerca volvulus | 0.0054 | 0.1034 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0419 | 0.0419 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.0419 | 0.0234 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0102 | 0.2826 | 0.2688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0039 | 0.0458 | 0.1018 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1034 | 0.086 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.0419 | 0.0419 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1034 | 0.2553 |
Onchocerca volvulus | 0.0054 | 0.1034 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1034 | 0.3201 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0419 | 0.0419 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1034 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0102 | 0.2826 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1034 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1034 | 0.3201 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0038 | 0.0419 | 0.087 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0419 | 0.087 |
Schistosoma mansoni | pol-related | 0.0038 | 0.0419 | 0.0234 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.0419 | 0.0234 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0054 | 0.1034 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0458 | 0.0041 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.0419 | 0.0419 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 41.8 uM | Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20958014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.