Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | endonuclease related | 0.0024 | 0.2216 | 0.2216 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0087 | 1 | 1 |
Echinococcus granulosus | Endonuclease G | 0.0024 | 0.2216 | 0.5262 |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0.2216 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.004 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3425 | 0.3425 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.4211 | 0.4211 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.4211 | 0.4211 |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0.2216 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0024 | 0.2216 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0006 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0.2216 | 1 |
Echinococcus multilocularis | Endonuclease G | 0.0024 | 0.2216 | 0.5262 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.4211 | 0.4211 |
Mycobacterium leprae | hypothetical protein | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.4211 | 0.4211 |
Mycobacterium ulcerans | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide | 0.0034 | 0.3425 | 0.8134 |
Trypanosoma cruzi | endonuclease G, putative | 0.0024 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Onchocerca volvulus | 0.0087 | 1 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0024 | 0.2216 | 0.5 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0006 | 0 | 0.5 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0024 | 0.2216 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.3425 | 0.8134 |
Onchocerca volvulus | 0.004 | 0.4211 | 0.4211 | |
Leishmania major | endonuclease G, putative | 0.0024 | 0.2216 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.3425 | 0.8134 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0024 | 0.2216 | 0.2216 |
Echinococcus multilocularis | ectonucleotide | 0.0034 | 0.3425 | 0.8134 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4211 | 0.4211 |
Onchocerca volvulus | 0.004 | 0.4211 | 0.4211 | |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0024 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0024 | 0.2216 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 170.3 nM | Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis | ChEMBL. | 22460025 |
Inhibition (binding) | = 86.1 % | Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate at 1 uM preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis | ChEMBL. | 22460025 |
Ki (binding) | = 40.1 uM | Inhibition of autotoxin assessed as choline release from LPC using lysophosphatidylcholine as substrate | ChEMBL. | 20951039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.