Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0177 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0177 | 0.0193 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0177 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.0177 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0177 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0177 | 0.0177 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0338 | 0.9185 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.1979 | 0.1979 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.1979 | 0.1979 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0177 | 0.0193 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0338 | 0.9185 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1145 | 0.1246 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0338 | 0.9185 | 1 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0338 | 0.9185 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.0177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0177 | 0.0193 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.0177 | 0.5 |
Echinococcus multilocularis | geminin | 0.0365 | 1 | 1 |
Onchocerca volvulus | 0.0039 | 0.0177 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0099 | 0.1979 | 0.2155 |
Schistosoma mansoni | hypothetical protein | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0144 | 0.3353 | 0.365 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.1979 | 0.1979 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0338 | 0.9185 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0177 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0247 | 0.6449 | 1 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0338 | 0.9185 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.0177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0177 | 0.0193 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0177 | 0.0193 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.1979 | 0.1979 |
Schistosoma mansoni | hypothetical protein | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0144 | 0.3353 | 0.365 |
Brugia malayi | Bm-MIF-1, identical | 0.0338 | 0.9185 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.2131 | 0.2321 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0338 | 0.9185 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.1979 | 0.1979 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0338 | 0.9185 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0177 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2131 | 0.2321 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0177 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0177 | 0.0193 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0338 | 0.9185 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0177 | 0.0177 |
Onchocerca volvulus | 0.0039 | 0.0177 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0177 | 0.0193 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1145 | 0.1145 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0177 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0099 | 0.1979 | 0.2155 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0177 | 0.0193 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.1979 | 0.1979 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0177 | 0.0193 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.0177 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0338 | 0.9185 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.2131 | 0.2321 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1145 | 0.1246 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0177 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.2131 | 0.2321 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0177 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.1979 | 0.1979 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8.56 ug ml-1 | Antimicrobial activity against Escherichia coli after 24 hrs by ELISA | ChEMBL. | 20934788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.