Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0032 | 0.1305 | 0.1305 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.1936 | 0.1936 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0396 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1936 | 0.1936 |
Echinococcus multilocularis | ectonucleotide | 0.0029 | 0.0841 | 0.4346 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Giardia lamblia | Rrm3p helicase | 0.0027 | 0.0396 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0027 | 0.0396 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0027 | 0.0396 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0841 | 0.0841 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0029 | 0.0841 | 0.4346 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0027 | 0.0396 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.1936 | 0.1936 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.1936 | 0.1936 |
Toxoplasma gondii | beta tubulin | 0.0025 | 0 | 0.5 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0027 | 0.0396 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0025 | 0 | 0.5 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0027 | 0.0396 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1936 | 0.1936 |
Plasmodium falciparum | tubulin beta chain | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0032 | 0.1305 | 0.1305 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0027 | 0.0396 | 0.2046 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0075 | 1 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0027 | 0.0396 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0035 | 0.1936 | 0.1936 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0027 | 0.0396 | 0.2046 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0027 | 0.0396 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0029 | 0.0841 | 0.4346 |
Onchocerca volvulus | 0.0075 | 1 | 1 | |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0027 | 0.0396 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1305 | 0.1305 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0027 | 0.0396 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.1936 | 0.1936 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1936 | 0.1936 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Echinococcus granulosus | ectonucleotide | 0.0029 | 0.0841 | 0.4346 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0396 | 0.0396 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.5 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 assessed as inhibition of fungal growth by alamar blue assay | ChEMBL. | 21130660 |
IC50 (functional) | = 15 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 assessed as inhibition of fungal growth by alamar blue assay | ChEMBL. | 21130660 |
MIC (functional) | > 20 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 by microscopy | ChEMBL. | 21130660 |
MIC (functional) | > 20 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 by microscopy | ChEMBL. | 21130660 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Candida albicans | ChEMBL23 | 21130660 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.