Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.005 | 0.1595 | 0.1826 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 1 |
Echinococcus granulosus | TNFR CD27 30 40 95 cysteine rich region | 0.0192 | 0.8737 | 1 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0126 | 0.5398 | 0.6179 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0126 | 0.5398 | 0.6179 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.1801 | 0.2062 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.5398 | 0.6179 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0192 | 0.8737 | 1 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0126 | 0.5398 | 0.6179 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5398 | 0.5398 |
Brugia malayi | Protein kinase domain containing protein | 0.0126 | 0.5398 | 0.5398 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0126 | 0.5398 | 0.6179 |
Echinococcus granulosus | death domain containing protein | 0.0126 | 0.5398 | 0.6179 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0126 | 0.5398 | 0.6179 |
Brugia malayi | Uncoordinated protein 44 | 0.0126 | 0.5398 | 0.5398 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.005 | 0.1595 | 0.1595 |
Echinococcus granulosus | Ankyrin | 0.0126 | 0.5398 | 0.6179 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0208 | 0.9557 | 1 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0192 | 0.8737 | 1 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0192 | 0.8737 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5398 | 0.5398 |
Onchocerca volvulus | Netrin receptor homolog | 0.0126 | 0.5398 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.005 | 0.1595 | 0.1826 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0126 | 0.5398 | 0.6179 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.0192 | 0.8737 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0126 | 0.5398 | 0.6179 |
Schistosoma mansoni | netrin receptor unc5 | 0.0126 | 0.5398 | 0.6179 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0126 | 0.5398 | 0.5398 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.1801 | 0.2062 |
Brugia malayi | Death domain containing protein | 0.0126 | 0.5398 | 0.5398 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0126 | 0.5398 | 0.5398 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.005 | 0.1595 | 0.1595 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 30.95 % | Inhibition of T-type alpha1G calcium channel expressed in HEK293 cells assessed as Kcl-induced depolarization at 10 uM | ChEMBL. | 21126876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.