Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | integrin alpha ps | 0.0148 | 0.061 | 0.1234 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0121 | 0.0143 | 0.5 |
Schistosoma mansoni | integrin alpha-ps | 0.0161 | 0.0833 | 0.1046 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.0286 | 0.0286 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.0286 | 0.0218 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0335 | 0.3869 | 0.5648 |
Echinococcus granulosus | integrin alpha ps | 0.0309 | 0.342 | 0.8652 |
Echinococcus multilocularis | integrin alpha 3 | 0.0338 | 0.3931 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0148 | 0.061 | 0.1234 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0121 | 0.0143 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.4154 | 0.4154 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0121 | 0.0143 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0499 | 0.6741 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0309 | 0.342 | 0.8652 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.0286 | 0.0286 |
Schistosoma mansoni | integrin alpha | 0.0499 | 0.6741 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3869 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1344 | 0.1344 |
Echinococcus granulosus | integrin alpha 3 | 0.0338 | 0.3931 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0121 | 0.0143 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.061 | 0.061 |
Schistosoma mansoni | hypothetical protein | 0.0148 | 0.061 | 0.0708 |
Schistosoma mansoni | integrin alpha-ps | 0.0309 | 0.342 | 0.4967 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0833 | 0.0833 |
Echinococcus multilocularis | integrin alpha ps | 0.0309 | 0.342 | 0.8652 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 50 uM | Induction of autophagy in human H4 cells expressing LC3 using DAPI staining after 4 hrs by fluorescence microscopic analysis | ChEMBL. | 21126871 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.