Detailed information for compound 1465804

Basic information

Technical information
  • TDR Targets ID: 1465804
  • Name: Oprea1_601160
  • MW: 254.37 | Formula: C17H22N2
  • H donors: 0 H acceptors: 0 LogP: 3.09 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCn2c3C1CCCc3c1c2c(C)ccc1
  • InChi: 1S/C17H22N2/c1-3-18-10-11-19-16-12(2)6-4-7-13(16)14-8-5-9-15(18)17(14)19/h4,6-7,15H,3,5,8-11H2,1-2H3
  • InChiKey: IACMCONNVAWCFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii diacylglycerol kinase, putative 0.0439 0 0.5
Plasmodium vivax diacylglycerol kinase, putative 0.0439 0 0.5
Schistosoma mansoni integrin beta subunit 0.0561 0.0113 0.0113
Mycobacterium tuberculosis Conserved protein 1.1276 1 1
Echinococcus multilocularis sphingosine kinase 1 1.1276 1 1
Onchocerca volvulus 0.0439 0 0.5
Leishmania major sphingosine kinase A, B, putative 0.0439 0 0.5
Trypanosoma brucei Sphingosine kinase 0.0439 0 0.5
Trypanosoma brucei diacylglycerol kinase, putative 0.0439 0 0.5
Trichomonas vaginalis diacylglycerol kinase, putative 0.0439 0 0.5
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0439 0 0.5
Trichomonas vaginalis diacylglycerol kinase, putative 0.0439 0 0.5
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0439 0 0.5
Schistosoma mansoni sphingoid long chain base kinase 1.1276 1 1
Schistosoma mansoni sphingosine kinase A B 1.1276 1 1
Brugia malayi Integrin beta pat-3 precursor 0.0976 0.0495 1
Loa Loa (eye worm) hypothetical protein 1.1276 1 1
Echinococcus multilocularis integrin beta 2 0.0714 0.0254 0.0254
Trichomonas vaginalis bmru protein, putative 0.0439 0 0.5
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0439 0 0.5
Plasmodium falciparum diacylglycerol kinase, putative 0.0439 0 0.5
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0439 0 0.5
Leishmania major diacylglycerol kinase, putative 0.0439 0 0.5
Trypanosoma cruzi diacylglycerol kinase, putative 0.0439 0 0.5
Entamoeba histolytica hypothetical protein, conserved 1.1276 1 1
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0439 0 0.5
Trichomonas vaginalis sphingosine kinase, putative 0.0439 0 0.5
Echinococcus granulosus integrin beta 2 0.0714 0.0254 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0439 0 0.5
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0439 0 0.5
Onchocerca volvulus Ceramide kinase 1 homolog 0.0439 0 0.5
Trypanosoma cruzi diacylglycerol kinase, putative 0.0439 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0439 0 0.5
Mycobacterium ulcerans hypothetical protein 1.1276 1 1
Loa Loa (eye worm) integrin beta-2 0.0976 0.0495 0.0495
Leishmania major hypothetical protein, conserved 0.0439 0 0.5
Trichomonas vaginalis sphingosine kinase, putative 0.0439 0 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0439 0 0.5
Plasmodium falciparum diacylglycerol kinase, putative 0.0439 0 0.5
Trypanosoma cruzi Sphingosine kinase 0.0439 0 0.5
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0439 0 0.5
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0439 0 0.5
Trichomonas vaginalis bmru protein, putative 0.0439 0 0.5
Plasmodium vivax diacylglycerol kinase, putative 0.0439 0 0.5
Leishmania major hypothetical protein, conserved 0.0439 0 0.5
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0439 0 0.5
Leishmania major diacylglycerol kinase-like protein 0.0439 0 0.5
Trypanosoma cruzi Sphingosine kinase 0.0439 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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