TDR Targets

Basic information

Technical information

TDR Targets ID: 1466003
Name: 8-chloro-1,5-dihydro-1,5-benzodiazepine-2,4-d ione
MW: 210.617 | Formula: C9H7ClN2O2
H donors: 2 H acceptors: 2 LogP: 0.81 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CC(=O)Nc2c(N1)cc(Cl)cc2
InChi: 1S/C9H7ClN2O2/c10-5-1-2-6-7(3-5)12-9(14)4-8(13)11-6/h1-3H,4H2,(H,11,13)(H,12,14)
InChiKey: YJSTZLNRIMXFOD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

8-chloro-1,5-dihydro-1,5-benzodiazepine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0196	0.8149	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0042
Echinococcus granulosus	GPCR family 2	0.0031	0.0121	0.0148
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0029	0.0018	0.000000073892
Trypanosoma brucei	oligopeptidase b	0.0069	0.1972	0.3271
Schistosoma mansoni	hypothetical protein	0.0031	0.0121	0.0126
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0069	0.1972	0.4017
Leishmania major	oligopeptidase b	0.0069	0.1972	0.2142
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0069	0.1972	0.7307
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0069	0.1972	0.3271
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0075	0.2287	0.2791
Trypanosoma brucei	prolyl endopeptidase	0.0151	0.5991	1
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0075	0.2287	0.3799
Schistosoma mansoni	hypothetical protein	0.0067	0.1864	0.227
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.4252	0.4923
Trichomonas vaginalis	set domain proteins, putative	0.0234	1	1
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0069	0.1972	0.3271
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.2376	0.5
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0123	0.4592	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0053	0.0042
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.4252	0.4923
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.2376	0.29
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0069	0.1972	0.3271
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0306	0.0334
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.1081	0.1327
Brugia malayi	Probable ClpP-like protease	0.0077	0.2376	0.2741
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0306	0.0334
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.2376	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.179	0.206
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0046	0.0876	0.2757
Schistosoma mansoni	hypothetical protein	0.0031	0.0121	0.0126
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.179	0.2967
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1864	0.2146
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0121	0.0119
Schistosoma mansoni	hypothetical protein	0.0031	0.0121	0.0126
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0876	0.0998
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.2376	0.3947
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0069	0.1972	0.3271
Brugia malayi	prolyl oligopeptidase family protein	0.0196	0.8149	0.9454
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0196	0.8149	0.8139
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.8618	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0306	0.021
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0876	0.2757
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0196	0.8149	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0121	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0053	0.004
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0151	0.5991	0.7347
Brugia malayi	hypothetical protein	0.0047	0.0887	0.1011
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0075	0.2287	0.2791
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.2376	1
Loa Loa (eye worm)	prolyl oligopeptidase	0.0196	0.8149	0.9454
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0046	0.0876	0.2757
Trypanosoma cruzi	oligopeptidase b	0.0069	0.1972	0.3271
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.2376	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0887	0.1011
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0069	0.1972	0.2142
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.2376	1
Brugia malayi	Pre-SET motif family protein	0.0205	0.8618	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.2376	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0876	0.2757
Brugia malayi	MH2 domain containing protein	0.0116	0.4252	0.4923
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0876	0.2757
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0151	0.5991	0.597
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0075	0.2287	0.3799
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.179	0.206
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0042
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.3366	0.3893
Loa Loa (eye worm)	hypothetical protein	0.0151	0.5991	0.6945
Plasmodium vivax	SET domain protein, putative	0.0029	0.0053	0.0147
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0151	0.5991	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.3366	0.3893
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0075	0.2287	0.3799
Entamoeba histolytica	acyl-coA synthetase, putative	0.0046	0.0876	0.4843
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0121	0.0126
Schistosoma mansoni	hypothetical protein	0.0031	0.0121	0.0126
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.1081	0.1308
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0306	0.1219
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0121	0.0119
Echinococcus multilocularis	prolyl endopeptidase	0.0151	0.5991	0.7347
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.2376	0.5
Onchocerca volvulus		0.0046	0.0876	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0306	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0121	0.0119
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0121	0.0119
Trypanosoma cruzi	prolyl endopeptidase	0.0151	0.5991	1
Mycobacterium ulcerans	hypothetical protein	0.0046	0.0876	0.2757
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0121	0.0148
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.2376	1
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0029	0.0018	0.5
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0454	0.0558
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.179	0.2967
Loa Loa (eye worm)	hypothetical protein	0.0098	0.3366	0.3893
Brugia malayi	prolyl oligopeptidase family protein	0.0075	0.2287	0.2638
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.1081	0.1367
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0306	0.1219
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0053	0.0042
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.179	0.1787
Trypanosoma cruzi	oligopeptidase b	0.0069	0.1972	0.3271
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.2376	0.3947
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0306	0.0334
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0121	0.0148
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0876	0.0998
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0046	0.0876	0.1514
Echinococcus granulosus	prolyl endopeptidase	0.0151	0.5991	0.7353
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.3366	0.3893
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0876	0.0998
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0046	0.0876	0.1514
Brugia malayi	prolyl oligopeptidase family protein	0.0151	0.5991	0.6945
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.1081	0.1982
Mycobacterium tuberculosis	Probable peptidase	0.0069	0.1972	0.4017
Echinococcus granulosus	acylamino acid releasing enzyme	0.0029	0.0018	0.0022
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0069	0.1972	0.8049
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.179	0.2179
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0075	0.2287	0.2758
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0306	0.0334
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0029	0.0018	0.5
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0151	0.5991	0.7347
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.2376	0.29
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0454	0.0536
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0046	0.0876	0.2757
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.2376	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0053	0.0058
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0121	0.0126
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.1864	0.2146
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.179	0.2179
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0053	0.0065
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0876	0.0998
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2376	0.2741
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.179	0.2967
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0876	0.0998
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.179	0.2197
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0046	0.0876	0.2757
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0046	0.0876	0.4843
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0196	0.8149	1
Toxoplasma gondii	prolyl endopeptidase	0.0151	0.5991	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0046	0.0876	0.4843
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0075	0.2287	0.3799
Brugia malayi	Pre-SET motif family protein	0.0029	0.0053	0.004
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0053	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0876	0.0998
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.2376	0.2916
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.1081	0.1982
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.179	1
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0075	0.2287	0.2807
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0075	0.2287	0.3799

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1642300

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1466003