Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0044 | 0.0018 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0063 | 0.0066 | 0.0696 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.0026 | 0.027 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0081 | 0.0093 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0066 | 0.0696 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0044 | 0.0018 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.1966 | 0.2935 | 0.2904 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.0044 | 1 |
Treponema pallidum | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) | 0.3854 | 0.5779 | 0.4025 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0066 | 0.0071 | 0.0746 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0048 | 0.0044 | 0.0018 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0048 | 0.0044 | 0.0018 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0081 | 0.0093 | 0.0978 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0044 | 0.0461 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0652 | 0.0955 | 1 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0081 | 0.0093 | 0.0804 |
Trichomonas vaginalis | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0652 | 0.0955 | 0.5 |
Echinococcus granulosus | folylpolyglutamate synthase mitochondrial | 0.0652 | 0.0955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0066 | 0.0696 |
Mycobacterium leprae | ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.6655 | 1 | 1 |
Trypanosoma cruzi | folylpolyglutamate synthase, putative | 0.0652 | 0.0955 | 1 |
Mycobacterium tuberculosis | Possible ligase | 0.0652 | 0.0955 | 0.0934 |
Onchocerca volvulus | 0.0048 | 0.0044 | 0.0063 | |
Mycobacterium ulcerans | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase | 0.3854 | 0.5779 | 0.5768 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0081 | 0.0093 | 0.0978 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.079 | 0.1162 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0093 | 0.0978 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.0044 | 0.0018 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0044 | 0.0018 |
Echinococcus granulosus | calpain A | 0.0066 | 0.0071 | 0.0746 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0048 | 0.0044 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0093 | 0.0978 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0652 | 0.0955 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0048 | 0.0044 | 0.0018 |
Toxoplasma gondii | bifunctional protein FolC subfamily protein | 0.0652 | 0.0955 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0063 | 0.0066 | 0.0696 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.0044 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.0026 | 0.0003 |
Mycobacterium ulcerans | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | 0.1966 | 0.2935 | 0.2917 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0044 | 0.0038 | 0.0401 |
Mycobacterium ulcerans | UDP-N-acetylmuramyl tripeptide synthase | 0.0652 | 0.0955 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.027 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.1966 | 0.2935 | 0.2919 |
Trypanosoma cruzi | folylpolyglutamate synthetase | 0.0652 | 0.0955 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0048 | 0.0044 | 0.0018 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0044 | 0.0461 |
Chlamydia trachomatis | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase | 0.1966 | 0.2935 | 0.2917 |
Echinococcus granulosus | folylpolyglutamate synthase, mitochondrial | 0.0652 | 0.0955 | 1 |
Chlamydia trachomatis | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 0.1966 | 0.2935 | 0.2917 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramate-alanine ligase | 0.3854 | 0.5779 | 0.5333 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0093 | 0.0978 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0044 | 0.0461 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramyl pentapeptide synthase | 0.6655 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0066 | 0.0071 | 0.0746 |
Treponema pallidum | UDP-N-acetylmuramate--L-alanine ligase | 0.3854 | 0.5779 | 0.4025 |
Brugia malayi | calpain family protein 1 | 0.0063 | 0.0066 | 0.0696 |
Treponema pallidum | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) | 0.6655 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0038 | 0.0401 |
Plasmodium falciparum | dihydrofolate synthase/folylpolyglutamate synthase | 0.0652 | 0.0955 | 1 |
Mycobacterium leprae | possible ligase | 0.0652 | 0.0955 | 0.0915 |
Mycobacterium tuberculosis | Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.6655 | 1 | 1 |
Schistosoma mansoni | apoptosis regulator bax | 0.0081 | 0.0093 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0044 | 0.0461 |
Brugia malayi | calpain family protein 1 | 0.0063 | 0.0066 | 0.0696 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0048 | 0.0044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0038 | 0.0401 |
Leishmania major | folylpolyglutamate synthetase | 0.0652 | 0.0955 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0044 | 0.0461 |
Trypanosoma brucei | folylpolyglutamate synthase, putative | 0.0652 | 0.0955 | 1 |
Mycobacterium ulcerans | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.6655 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.027 |
Brugia malayi | FolC bifunctional protein | 0.0652 | 0.0955 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0093 | 0.0978 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0044 | 0.0038 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0044 | 0.0461 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramyl tripeptide synthase | 0.1966 | 0.2935 | 0.2189 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.027 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0652 | 0.0955 | 0.8216 |
Mycobacterium ulcerans | UDP-N-acetylmuramate--L-alanine ligase | 0.3854 | 0.5779 | 0.5768 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0081 | 0.0093 | 0.0804 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0044 | 0.0461 |
Loa Loa (eye worm) | FolC protein | 0.0652 | 0.0955 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0048 | 0.0044 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.027 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0081 | 0.0093 | 0.0978 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0081 | 0.0093 | 0.0978 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0066 | 0.0071 | 0.0746 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0044 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0044 | 0.0461 |
Plasmodium vivax | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0652 | 0.0955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.027 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0066 | 0.0071 | 0.0613 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.1966 | 0.2935 | 0.2917 |
Echinococcus multilocularis | calpain A | 0.0066 | 0.0071 | 0.0613 |
Chlamydia trachomatis | bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase | 0.3854 | 0.5779 | 0.5768 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0652 | 0.0955 | 0.8216 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to substrate binding site of multidrug resistance Mycobacterium tuberculosis antigen 85C by NMR assay | ChEMBL. | 21073150 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.