Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.065 | 0.0531 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.0953 | 0.2474 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.065 | 0.2007 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.0953 | 0.2942 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.2355 | 0.7269 |
Echinococcus granulosus | geminin | 0.0191 | 0.2355 | 0.6114 |
Brugia malayi | Cell division protein ftsZ | 0.0175 | 0.1931 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0129 | 0.065 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.011 | 0.0126 | 0.0651 |
Treponema pallidum | cell division protein FtsZ | 0.0355 | 0.6887 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0129 | 0.065 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.324 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.3852 | 1 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0355 | 0.6887 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0129 | 0.065 | 0.3366 |
Mycobacterium leprae | cell division protein FtsZ | 0.0355 | 0.6887 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0129 | 0.065 | 0.1688 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.065 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0129 | 0.065 | 0.5 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0355 | 0.6887 | 0.5 |
Echinococcus multilocularis | geminin | 0.0191 | 0.2355 | 0.7269 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.011 | 0.0126 | 0.0651 |
Onchocerca volvulus | 0.0129 | 0.065 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.2355 | 0.7269 |
Brugia malayi | Cell division protein ftsZ | 0.017 | 0.1796 | 0.9302 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0.065 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0129 | 0.065 | 0.0531 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0355 | 0.6887 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0129 | 0.065 | 0.2007 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.324 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0129 | 0.065 | 0.3366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.