Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = -3.8 % | Growth inhibition of human MCF7 cells at 25 ug/ml after 24 hrs by MTT colorimetric assay | ChEMBL. | 21035921 |
GI (functional) | = 12.2 % | Growth inhibition of human MCF7 cells at 50 ug/ml after 24 hrs by MTT colorimetric assay | ChEMBL. | 21035921 |
GI (functional) | = 14.5 % | Growth inhibition of human MDA-MB-231 cells at 25 ug/ml after 24 hrs by MTT colorimetric assay | ChEMBL. | 21035921 |
GI (functional) | = 41.9 % | Growth inhibition of human MDA-MB-231 cells at 50 ug/ml after 24 hrs by MTT colorimetric assay | ChEMBL. | 21035921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.