Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adam | 0.0267 | 0.0445 | 0.103 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0255 | 0.0398 | 0.5158 |
Loa Loa (eye worm) | matrixin family protein | 0.0364 | 0.0825 | 0.0825 |
Echinococcus granulosus | adam | 0.0267 | 0.0445 | 0.0904 |
Echinococcus granulosus | transient receptor potential cation channel | 0.122 | 0.4169 | 0.8478 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0504 | 0.1372 | 0.279 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.1199 | 0.4087 | 0.9461 |
Brugia malayi | Disintegrin family protein | 0.0227 | 0.0288 | 0.1478 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.122 | 0.417 | 0.9653 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.0039 | 0.009 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.1258 | 0.432 | 1 |
Brugia malayi | hypothetical protein | 0.0267 | 0.0445 | 0.2409 |
Loa Loa (eye worm) | matrixin family protein | 0.0255 | 0.0398 | 0.0398 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0227 | 0.0288 | 0.0666 |
Onchocerca volvulus | Matrilysin homolog | 0.0341 | 0.0735 | 1 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0594 | 0.1724 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.1258 | 0.432 | 1 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0594 | 0.1724 | 0.3992 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0504 | 0.1372 | 0.3176 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0857 | 0.2751 | 0.6369 |
Echinococcus granulosus | ankyrin repeat protein | 0.1199 | 0.4087 | 0.831 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0227 | 0.0288 | 0.0666 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0227 | 0.0288 | 0.0585 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0594 | 0.1724 | 0.3992 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0201 | 0.0188 | 0.0436 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0267 | 0.0445 | 0.103 |
Echinococcus granulosus | adam 17 protease | 0.1411 | 0.4918 | 1 |
Echinococcus multilocularis | ankyrin repeat protein | 0.1199 | 0.4087 | 0.9461 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0188 | 0.0188 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0857 | 0.2751 | 0.5594 |
Brugia malayi | Matrixin family protein | 0.0364 | 0.0825 | 0.4665 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0594 | 0.1724 | 0.3506 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 10 mg kg-1 | Oral effective dose against LPS stimulated TNF-alpha release in mice. | ChEMBL. | 11472217 |
ED50 (functional) | > 10 mg kg-1 | Oral effective dose against LPS stimulated TNF-alpha release in mice. | ChEMBL. | 11472217 |
IC50 (functional) | = 0.15 uM | Inhibition of LPS-stimulated TNF-alpha release in human whole blood | ChEMBL. | 11472217 |
IC50 (functional) | = 0.15 uM | Inhibition of LPS-stimulated TNF-alpha release in human whole blood | ChEMBL. | 11472217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.