Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Trichomonas vaginalis | diacylglycerol kinase, zeta, iota, putative | 0.0282 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.7243 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0282 | 0 | 0.5 |
Trypanosoma cruzi | Sphingosine kinase | 0.0282 | 0 | 0.5 |
Plasmodium falciparum | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Brugia malayi | Diacylglycerol kinase protein 2 | 0.0282 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol kinase-like protein, putative | 0.0282 | 0 | 0.5 |
Trichomonas vaginalis | sphingosine kinase, putative | 0.0282 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.7243 | 1 | 1 |
Schistosoma mansoni | sphingosine kinase A B | 0.7243 | 1 | 1 |
Trichomonas vaginalis | sphingosine kinase, putative | 0.0282 | 0 | 0.5 |
Brugia malayi | diacylglycerol kinase | 0.0282 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0282 | 0 | 0.5 |
Onchocerca volvulus | 0.0282 | 0 | 0.5 | |
Echinococcus multilocularis | sphingosine kinase 1 | 0.7243 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0282 | 0 | 0.5 |
Trichomonas vaginalis | diacylglycerol kinase, zeta, iota, putative | 0.0282 | 0 | 0.5 |
Trichomonas vaginalis | diacylglycerol kinase, epsilon, putative | 0.0282 | 0 | 0.5 |
Plasmodium vivax | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Trichomonas vaginalis | bmru protein, putative | 0.0282 | 0 | 0.5 |
Onchocerca volvulus | Ceramide kinase 1 homolog | 0.0282 | 0 | 0.5 |
Toxoplasma gondii | diacylglycerol kinase accessory domain (presumed) domain-containing protein | 0.0282 | 0 | 0.5 |
Trypanosoma cruzi | Diacylglycerol kinase catalytic domain containing protein, putative | 0.0282 | 0 | 0.5 |
Trichomonas vaginalis | bmru protein, putative | 0.0282 | 0 | 0.5 |
Brugia malayi | diacylglycerol kinase | 0.0282 | 0 | 0.5 |
Toxoplasma gondii | diacylglycerol kinase catalytic domain-containing protein | 0.0282 | 0 | 0.5 |
Trypanosoma cruzi | Sphingosine kinase | 0.0282 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.7243 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0282 | 0 | 0.5 |
Brugia malayi | Eye-specific diacylglycerol kinase | 0.0282 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0282 | 0 | 0.5 |
Leishmania major | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Trypanosoma brucei | Sphingosine kinase | 0.0282 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0282 | 0 | 0.5 |
Trichomonas vaginalis | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Brugia malayi | Ceramide kinase | 0.0282 | 0 | 0.5 |
Trypanosoma brucei | Diacylglycerol kinase catalytic domain containing protein, putative | 0.0282 | 0 | 0.5 |
Trichomonas vaginalis | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol kinase-like protein, putative | 0.0282 | 0 | 0.5 |
Plasmodium vivax | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.7243 | 1 | 1 |
Plasmodium falciparum | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Leishmania major | sphingosine kinase A, B, putative | 0.0282 | 0 | 0.5 |
Schistosoma mansoni | sphingoid long chain base kinase | 0.7243 | 1 | 1 |
Leishmania major | diacylglycerol kinase-like protein | 0.0282 | 0 | 0.5 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0282 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.57 uM | Inhibition of Mycobacterium tuberculosis Thymidine monophosphate kinase by spectrophotometry | ChEMBL. | 20951473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.