Detailed information for compound 1470938

Basic information

Technical information
  • TDR Targets ID: 1470938
  • Name: N-[2-(2,3,5-trimethylphenoxy)ethyl]butan-2-am ine
  • MW: 235.365 | Formula: C15H25NO
  • H donors: 1 H acceptors: 0 LogP: 3.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NCCOc1cc(C)cc(c1C)C)C
  • InChi: 1S/C15H25NO/c1-6-13(4)16-7-8-17-15-10-11(2)9-12(3)14(15)5/h9-10,13,16H,6-8H2,1-5H3
  • InChiKey: XIUBFULPZMVJOZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • sec-butyl-[2-(2,3,5-trimethylphenoxy)ethyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni plexin 0.0642 0.4966 1
Echinococcus granulosus epidermal growth factor receptor 0.0208 0.0968 0.0968
Echinococcus granulosus transcription factor collier 0.0117 0.0134 0.0134
Echinococcus granulosus semaphorin 5B 0.0268 0.1523 0.1523
Echinococcus granulosus semaphorin 1A 0.0268 0.1523 0.1523
Onchocerca volvulus Tyrosine kinase homolog 0.0343 0.2211 0.1999
Brugia malayi Furin-like cysteine rich region family protein 0.0351 0.2286 0.3639
Schistosoma mansoni tyrosine kinase 0.0141 0.0348 0.0443
Loa Loa (eye worm) TK/INSR protein kinase 0.0141 0.0348 0.0575
Echinococcus multilocularis exocyst complex component 2 0.0117 0.0134 0.0221
Echinococcus multilocularis epidermal growth factor receptor 0.0351 0.2286 0.3779
Loa Loa (eye worm) hypothetical protein 0.0268 0.1523 0.2517
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0134 0.5
Schistosoma mansoni tyrosine kinase 0.0164 0.0565 0.0893
Loa Loa (eye worm) hypothetical protein 0.0268 0.1523 0.2517
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0208 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0642 0.4966 0.821
Loa Loa (eye worm) hypothetical protein 0.0268 0.1523 0.2517
Brugia malayi Sema domain containing protein 0.0268 0.1523 0.2348
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0141 0.0348 0.0348
Echinococcus multilocularis transcription factor collier 0.0117 0.0134 0.0221
Echinococcus granulosus epidermal growth factor receptor 0.0351 0.2286 0.2286
Loa Loa (eye worm) hypothetical protein 0.0117 0.0134 0.0221
Schistosoma mansoni semaphorin 5-related 0.0268 0.1523 0.2874
Brugia malayi Immunoglobulin I-set domain containing protein 0.0419 0.2918 0.4707
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0141 0.0348 0.0575
Loa Loa (eye worm) hypothetical protein 0.0374 0.2495 0.4124
Entamoeba histolytica protein kinase domain containing protein 0.0161 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0134 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0134 0.5
Brugia malayi plexin A 0.0759 0.6049 1
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0117 0.0134 0.5
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0117 0.0134 0.5
Schistosoma mansoni hypothetical protein 0.0268 0.1523 0.2874
Loa Loa (eye worm) hypothetical protein 0.0117 0.0134 0.0221
Echinococcus multilocularis plexin a4 0.0759 0.6049 1
Schistosoma mansoni tyrosine kinase 0.0164 0.0565 0.0893
Echinococcus granulosus insulin receptor 0.0141 0.0348 0.0348
Loa Loa (eye worm) sema domain-containing protein 0.0268 0.1523 0.2517
Loa Loa (eye worm) plexin A 0.0759 0.6049 1
Brugia malayi Plexin repeat family protein 0.0642 0.4966 0.8169
Schistosoma mansoni tyrosine kinase 0.0208 0.0968 0.1726
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0268 0.1523 0.2517
Echinococcus multilocularis hypothetical protein 0.0268 0.1523 0.2517
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0134 0.5
Onchocerca volvulus 0.0286 0.1687 0.0479
Brugia malayi Protein kinase domain containing protein 0.0141 0.0348 0.0362
Schistosoma mansoni tyrosine kinase 0.0141 0.0348 0.0443
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0419 0.2918 0.4824
Schistosoma mansoni tyrosine kinase 0.0351 0.2286 0.4454
Schistosoma mansoni tyrosine kinase 0.0164 0.0565 0.0893
Brugia malayi Sema domain containing protein 0.0268 0.1523 0.2348
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0134 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0134 0.5
Schistosoma mansoni plexin 0.0374 0.2495 0.4885
Brugia malayi hypothetical protein 0.0268 0.1523 0.2348
Echinococcus multilocularis epidermal growth factor receptor 0.0208 0.0968 0.16
Echinococcus multilocularis insulin receptor 0.0141 0.0348 0.0575
Loa Loa (eye worm) hypothetical protein 0.0268 0.1523 0.2517
Schistosoma mansoni hypothetical protein 0.0268 0.1523 0.2874
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0117 0.0134 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0161 0.0536 1
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0117 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0.0134 0.0221
Schistosoma mansoni tyrosine kinase 0.0208 0.0968 0.1726
Loa Loa (eye worm) sema domain-containing protein 0.0268 0.1523 0.2517
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0268 0.1523 0.2517
Echinococcus granulosus plexin a4 0.0759 0.6049 0.6049
Echinococcus multilocularis semaphorin 5B 0.0268 0.1523 0.2517
Echinococcus granulosus exocyst complex component 2 0.0117 0.0134 0.0134
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0117 0.0134 0.5
Schistosoma mansoni hypothetical protein 0.0374 0.2495 0.4885
Brugia malayi hypothetical protein 0.0268 0.1523 0.2348
Onchocerca volvulus 0.0642 0.4966 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0351 0.2286 0.3779

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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