Detailed information for compound 1471641

Basic information

Technical information
  • TDR Targets ID: 1471641
  • Name: 3-(benzoyl)-2-phenylindolizine-7-carboxylic a cid
  • MW: 341.359 | Formula: C22H15NO3
  • H donors: 1 H acceptors: 3 LogP: 5.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c(cc2n1ccc(c2)C(=O)O)c1ccccc1)c1ccccc1
  • InChi: 1S/C22H15NO3/c24-21(16-9-5-2-6-10-16)20-19(15-7-3-1-4-8-15)14-18-13-17(22(25)26)11-12-23(18)20/h1-14H,(H,25,26)
  • InChiKey: MDUKTVJKQXUSHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(benzoyl)-2-phenyl-indolizine-7-carboxylic acid
  • 3-(oxo-phenylmethyl)-2-phenyl-7-indolizinecarboxylic acid
  • 2-phenyl-3-phenylcarbonyl-indolizine-7-carboxylic acid
  • IDI1_030462
  • Oprea1_861646
  • ChemDiv3_014664

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Tr4/Tr2 (homologue) 0.019 0.7174 0.8836
Loa Loa (eye worm) TAR-binding protein 0.0077 0.1298 0.1298
Echinococcus granulosus ecdysone induced protein 78C 0.019 0.7174 0.8836
Brugia malayi TAR-binding protein 0.0077 0.1298 0.1298
Brugia malayi orphan nuclear receptor NR2E1 0.009 0.1943 0.1943
Schistosoma mansoni thyroid hormone receptor 0.019 0.7174 0.8836
Loa Loa (eye worm) nuclear hormone receptor 0.009 0.1943 0.1943
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.1943 0.0969
Echinococcus multilocularis ecdysone induced protein 78C 0.019 0.7174 0.8836
Loa Loa (eye worm) acetylcholinesterase 1 0.0078 0.1353 0.1353
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.1943 0.0969
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.019 0.7174 0.8836
Loa Loa (eye worm) nuclear receptor nhr-7B 0.009 0.1943 0.1943
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.019 0.7174 0.8836
Echinococcus granulosus FTZ F1 alpha 0.019 0.7174 0.8836
Echinococcus granulosus nuclear receptor 2DBD gamma 0.019 0.7174 0.8836
Loa Loa (eye worm) hypothetical protein 0.019 0.7174 0.7174
Loa Loa (eye worm) hypothetical protein 0.019 0.7174 0.7174
Brugia malayi Carboxylesterase family protein 0.0078 0.1353 0.1353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.019 0.7174 0.7174
Loa Loa (eye worm) hypothetical protein 0.01 0.2503 0.2503
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.009 0.1943 0.0969
Echinococcus granulosus carboxylesterase 5A 0.0078 0.1353 0.0083
Echinococcus granulosus thyroid hormone receptor alpha 0.009 0.1943 0.0969
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.1353 0.0083
Schistosoma mansoni RAR-like nuclear receptor 0.019 0.7174 0.8836
Echinococcus multilocularis carboxylesterase 5A 0.0078 0.1353 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-1 0.019 0.7174 0.7174
Schistosoma mansoni retinoic acid receptor RXR 0.019 0.7174 0.8836
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.019 0.7174 0.8836
Loa Loa (eye worm) DR-78 0.009 0.1943 0.1943
Brugia malayi RNA binding protein 0.0077 0.1298 0.1298
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.019 0.7174 0.7174
Schistosoma mansoni steroid hormone receptor ad4bp 0.019 0.7174 0.8836
Loa Loa (eye worm) hypothetical protein 0.01 0.2503 0.2503
Schistosoma mansoni nuclear hormone receptor 0.009 0.1943 0.0969
Loa Loa (eye worm) nuclear receptor NHR-67 0.009 0.1943 0.1943
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.019 0.7174 0.8836
Brugia malayi nuclear hormone receptor 0.019 0.7174 0.7174
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.1943 0.0969
Schistosoma mansoni nuclear receptor 0.009 0.1943 0.0969
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.1943 0.0969
Echinococcus multilocularis thyroid hormone receptor alpha 0.019 0.7174 0.8836
Echinococcus multilocularis geminin 0.0205 0.7948 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.01 0.2503 0.1812
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Brugia malayi Nuclear hormone receptor family member nhr-40 0.019 0.7174 0.7174
Brugia malayi Nuclear hormone receptor family member nhr-31 0.019 0.7174 0.7174
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.009 0.1943 0.0969
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.019 0.7174 0.8836
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0077 0.1298 0.1298
Loa Loa (eye worm) hypothetical protein 0.019 0.7174 0.7174
Brugia malayi hypothetical protein 0.01 0.2503 0.2503
Brugia malayi Nuclear hormone receptor family member nhr-3 0.019 0.7174 0.7174
Loa Loa (eye worm) hypothetical protein 0.01 0.2503 0.2503
Brugia malayi nuclear receptor RXR 0.01 0.2503 0.2503
Brugia malayi ecdysone receptor 0.009 0.1943 0.1943
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.01 0.2503 0.1812
Brugia malayi nuclear receptor RXR 0.009 0.1943 0.1943
Brugia malayi nuclear hormone receptor family member nhr-6 0.009 0.1943 0.1943
Brugia malayi hypothetical protein 0.009 0.1943 0.1943
Echinococcus granulosus nuclear receptor nhr 48 0.009 0.1943 0.0969
Brugia malayi hypothetical protein 0.01 0.2503 0.2503
Loa Loa (eye worm) hypothetical protein 0.0078 0.1353 0.1353
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.019 0.7174 0.7174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.019 0.7174 0.7174
Onchocerca volvulus Bile acid receptor homolog 0.019 0.7174 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.019 0.7174 0.8836
Loa Loa (eye worm) hypothetical protein 0.0078 0.1353 0.1353
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.009 0.1943 0.0969
Loa Loa (eye worm) hypothetical protein 0.019 0.7174 0.7174
Brugia malayi RNA recognition motif domain containing protein 0.0077 0.1298 0.1298
Schistosoma mansoni coup transcription factor 0.019 0.7174 0.8836
Loa Loa (eye worm) hypothetical protein 0.01 0.2503 0.2503
Echinococcus granulosus acetylcholinesterase 0.0078 0.1353 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.019 0.7174 0.7174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.1943 0.0969
Schistosoma mansoni nuclear receptor 0.009 0.1943 0.0969
Brugia malayi Nuclear hormone receptor family member nhr-49 0.019 0.7174 0.7174
Schistosoma mansoni thyroid hormone receptor 0.019 0.7174 0.8836
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.009 0.1943 0.0969
Echinococcus multilocularis acetylcholinesterase 0.0078 0.1353 0.0083
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.019 0.7174 0.8836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.019 0.7174 0.7174
Brugia malayi nuclear receptor NHR-88 0.019 0.7174 0.7174
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.01 0.2503 0.2503
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.2503 0.1812
Brugia malayi tailless protein 0.009 0.1943 0.1943
Loa Loa (eye worm) hypothetical protein 0.019 0.7174 0.7174
Brugia malayi Carboxylesterase family protein 0.0078 0.1353 0.1353
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.1943 0.0969
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.019 0.7174 0.8836
Brugia malayi nuclear hormone receptor family member odr-7 0.009 0.1943 0.1943
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.019 0.7174 0.8836
Echinococcus granulosus retinoic acid receptor rxr beta a 0.019 0.7174 0.8836
Brugia malayi Steroid receptor seven-up type 2 0.019 0.7174 0.7174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.019 0.7174 0.7174
Loa Loa (eye worm) hypothetical protein 0.01 0.2503 0.2503
Loa Loa (eye worm) carboxylesterase 0.0078 0.1353 0.1353
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.2503 0.2503
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.019 0.7174 0.8836
Brugia malayi nuclear receptor NHR-88 0.009 0.1943 0.1943
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.019 0.7174 0.7174
Schistosoma mansoni nuclear hormone receptor 0.019 0.7174 0.8836
Echinococcus granulosus geminin 0.0205 0.7948 1
Loa Loa (eye worm) hypothetical protein 0.019 0.7174 0.7174
Brugia malayi ecdysteroid receptor 0.019 0.7174 0.7174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.019 0.7174 0.8836
Onchocerca volvulus 0.019 0.7174 1
Loa Loa (eye worm) hypothetical protein 0.019 0.7174 0.7174
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.01 0.2503 0.1812
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.019 0.7174 0.8836
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.019 0.7174 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.019 0.7174 0.7174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.019 0.7174 0.7174
Schistosoma mansoni zinc finger protein 0.009 0.1943 0.0969
Brugia malayi nuclear hormone receptor 0.009 0.1943 0.1943
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.009 0.1943 0.0969
Brugia malayi Nuclear hormone receptor family member nhr-25 0.019 0.7174 0.7174
Schistosoma mansoni hypothetical protein 0.0205 0.7948 1
Loa Loa (eye worm) RNA binding protein 0.0077 0.1298 0.1298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.019 0.7174 0.8836
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Echinococcus multilocularis acetylcholinesterase 0.0078 0.1353 0.0083
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Brugia malayi Nuclear hormone receptor family member nhr-14 0.019 0.7174 0.7174
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Schistosoma mansoni retinoid-x-receptor (RXR) 0.019 0.7174 0.8836
Brugia malayi Nuclear hormone receptor family member nhr-41 0.019 0.7174 0.7174
Brugia malayi Nuclear hormone receptor-like 1 0.019 0.7174 0.7174
Brugia malayi steroid hormone receptor 0.019 0.7174 0.7174
Echinococcus multilocularis nuclear receptor nhr 48 0.009 0.1943 0.0969
Schistosoma mansoni nuclear receptor nhr-48 0.009 0.1943 0.0969
Loa Loa (eye worm) steroid hormone receptor 0.019 0.7174 0.7174
Brugia malayi conserved hypotetical protein 0.009 0.1943 0.1943
Brugia malayi nuclear receptor NHR-67 0.009 0.1943 0.1943
Brugia malayi photoreceptor-specific nuclear receptor 0.019 0.7174 0.7174
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Schistosoma mansoni hypothetical protein 0.0205 0.7948 1
Onchocerca volvulus Protein ultraspiracle homolog 0.019 0.7174 1
Brugia malayi Nuclear hormone receptor E75 0.009 0.1943 0.1943
Echinococcus multilocularis FTZ F1 alpha 0.019 0.7174 0.8836
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.2503 0.2503
Brugia malayi Nuclear hormone receptor family member nhr-19 0.019 0.7174 0.7174
Brugia malayi Nuclear hormone receptor E75 0.009 0.1943 0.1943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.019 0.7174 0.7174
Schistosoma mansoni nuclear hormone receptor 0.009 0.1943 0.0969
Loa Loa (eye worm) hypothetical protein 0.019 0.7174 0.7174
Echinococcus granulosus acetylcholinesterase 0.0078 0.1353 0.0083
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.019 0.7174 0.8836
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.019 0.7174 0.8836
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.009 0.1943 0.1943
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Loa Loa (eye worm) hypothetical protein 0.009 0.1943 0.1943
Brugia malayi hypothetical protein 0.009 0.1943 0.1943

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.