TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.449 | Formula: C18H20N5OS+
H donors: 1 H acceptors: 0 LogP: 3.81 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CSC(=N)N/N=C/c1ccc(cc1)c1cn2c([n+]1C)ccc(c2)OC
InChi: 1S/C18H20N5OS/c1-22-16(12-23-11-15(24-2)8-9-17(22)23)14-6-4-13(5-7-14)10-20-21-18(19)25-3/h4-12H,1-3H3,(H2,19,21)/q+1/b20-10+
InChiKey: OIBSVVFFUYKQDQ-KEBDBYFISA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide receptor A26	0.0021	0.0051	0.0048
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0051	0.0048
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0021	0.0051	0.0048
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0009	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0011	0.0003	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0015	0.0021	0.0018
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0048	0.0045
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.0051	0.0048
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0015	0.0021	0.0018
Echinococcus granulosus	nervana 2	0.002	0.0048	0.0045
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0026	0.0074	0.0071
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0015	0.0021	0.0018
Schistosoma mansoni	atypical protein kinase C	0.0031	0.0103	0.01
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.0051	0.0048
Schistosoma mansoni	amine GPCR	0.0021	0.0051	0.0048
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0051	0.0048
Entamoeba histolytica	protein kinase, putative	0.0046	0.0174	0.7431
Entamoeba histolytica	protein kinase 2, putative	0.0027	0.0082	0.3434
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0007	0.0004
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0051	0.005
Entamoeba histolytica	protein kinase, putative	0.0048	0.0184	0.7867
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0051	0.0048
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0051	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0109	0.0482	1
Brugia malayi	Protein kinase c protein 2	0.0053	0.021	0.0207
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Schistosoma mansoni	serine/threonine-protein kinase	0.0029	0.0092	0.0089
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0012	0.0007	0.0006
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0015	0.0021	0.0018
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0072	0.0302	0.0299
Entamoeba histolytica	protein kinase, putative	0.0026	0.0074	0.3078
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.0051	0.0048
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0074	0.0071
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	adapter molecule crk	0.0012	0.0009	0.0006
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0015	0.0021	0.0018
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0015	0.0021	0.0018
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0026	0.0074	0.0071
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus multilocularis	neuropeptide s receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	serine threonine protein kinase	0.0066	0.0272	0.0269
Leishmania major	protein kinase, putative	0.0058	0.0233	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0074	0.0073
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Echinococcus multilocularis	protein kinase c epsilon type	0.0033	0.0109	0.0106
Brugia malayi	G protein-coupled receptor	0.0021	0.0051	0.0048
Trypanosoma cruzi	Protein kinase B	0.0029	0.0092	0.0664
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0026	0.0074	0.0071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0011	0.0003	0.0628
Echinococcus granulosus	hypothetical protein	0.0021	0.0051	0.0048
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0048	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0427	0.2048	0.2047
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	growth factor receptor-bound protein	0.0012	0.0009	0.0006
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0051	0.0048
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0051	0.0048
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0026	0.0074	0.0071
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0051	0.0048
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0074	0.0071
Schistosoma mansoni	myosin xvIII	0.0021	0.0051	0.0048
Schistosoma mansoni	tyrosine kinase	0.0015	0.0021	0.0018
Schistosoma mansoni	tyrosine kinase	0.0015	0.0021	0.0018
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0033	0.0109	0.0108
Echinococcus granulosus	nervana 2	0.002	0.0048	0.0045
Echinococcus multilocularis	serotonin receptor	0.0427	0.2048	0.2046
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0051	0.005
Echinococcus granulosus	protein kinase C gamma type	0.0066	0.0272	0.0269
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0302	0.0299
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	tyrosine kinase	0.0015	0.0021	0.0018
Brugia malayi	neuropeptide F receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0021	0.0051	1
Onchocerca volvulus		0.0021	0.0051	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0051	0.005
Giardia lamblia	Kinase, NEK	0.0109	0.0482	1
Loa Loa (eye worm)	TK protein kinase	0.0011	0.0003	0.0002
Giardia lamblia	Kinase, NEK	0.0109	0.0482	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.0051	0.0048
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0109	0.0106
Schistosoma mansoni	hypothetical protein	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0184	0.3248
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0021	0.0051	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0051	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0184	0.3248
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0015	0.0021	0.0017
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0048	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	sex peptide receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	opsin-like receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.2043	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0013	0.0012	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Echinococcus granulosus	NCK adaptor protein	0.0012	0.0009	0.0006
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0047	0.0181	0.0179
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Trichomonas vaginalis	STE family protein kinase	0.0058	0.0233	0.4355
Onchocerca volvulus		0.0021	0.0051	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Schistosoma mansoni	ste20-related kinase	0.0177	0.0817	0.0814
Brugia malayi	RhoGAP domain containing protein	0.0015	0.0021	0.0017
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0012	0.0009	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0051	0.0048
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0051	0.0048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0051	0.0048
Brugia malayi	AKH receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0012	0.0009	0.0008
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0021	0.0051	1
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0051	0.0048
Toxoplasma gondii	NIMA-related protein kinase NIMA1	0.0109	0.0482	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus granulosus	serine threonine protein kinase nrc	0.0027	0.0082	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Plasmodium vivax	NIMA-related protein kinase (Pfnek-1), putative	0.0109	0.0482	1
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0074	0.0763
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0051	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0074	0.0071
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0051	0.005
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0029	0.0092	0.387
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Schistosoma mansoni	amine GPCR	0.0749	0.3636	0.3634
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Schistosoma mansoni	growth factor receptor-bound protein	0.0012	0.0009	0.0006
Echinococcus granulosus	neuropeptide s receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0051	0.0048
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0027	0.0082	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0045	0.017	0.0169
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Entamoeba histolytica	protein kinase, putative	0.0048	0.0184	0.7867
Echinococcus granulosus	somatostatin receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	RE15519p	0.0021	0.0051	0.0048
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0015	0.0021	0.0017
Trichomonas vaginalis	STE family protein kinase	0.0109	0.0482	1
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0184	0.3248
Onchocerca volvulus		0.0021	0.0051	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0011	0.0003	0.0628
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Brugia malayi	p70 ribosomal S6 kinase beta	0.0046	0.0174	0.0171
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0427	0.2048	0.2046
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0051	0.0048
Brugia malayi	protein kinase C3,putative	0.0013	0.0012	0.0008
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0015	0.0021	0.0018
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.2043	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0015	0.0021	0.0018
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0012	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Onchocerca volvulus		0.0021	0.0051	1
Schistosoma mansoni	tyrosine kinase	0.0015	0.0021	0.0018
Onchocerca volvulus		0.0011	0.0003	0.0628
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Entamoeba histolytica	serine/threonine protein kinase STE20, putative	0.0058	0.0233	1
Onchocerca volvulus		0.0021	0.0051	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0021	0.0051	1
Brugia malayi	putative neuropeptide receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0141	0.0139
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0026	0.0074	0.0073
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0051	0.0048
Echinococcus granulosus	N chimaerin	0.0015	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Loa Loa (eye worm)	STE/STE20/MST protein kinase	0.0227	0.1068	0.1067
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0039	0.0141	0.0137
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	amine GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	N chimaerin	0.0015	0.0021	0.0017
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0051	0.0048
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0051	0.0048
Brugia malayi	C1-like domain containing protein	0.0013	0.0012	0.0008
Schistosoma mansoni	nck2/grb4	0.0012	0.0009	0.0006
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0051	0.0048
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0021	0.0051	1
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0051	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0184	0.0181
Echinococcus multilocularis	somatostatin receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0021	0.0051	1
Echinococcus granulosus	RNA directed DNA polymerase	0.0039	0.0141	0.0137
Echinococcus multilocularis	NCK adaptor protein	0.0012	0.0009	0.0006
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.0051	0.0048
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0015	0.0021	0.0017
Schistosoma mansoni	opsin-like receptor	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0021	0.0051	1
Schistosoma mansoni	serine/threonine protein kinase	0.2043	1	1
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0011	0.0003	0.0628
Brugia malayi	Dopamine receptor	0.0021	0.0051	0.0048
Brugia malayi	protein kinase C II.	0.0033	0.0109	0.0106
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0051	0.005
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0015	0.0021	0.0018
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0051	0.005
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0051	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0084	0.0989
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0051	0.0048
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0011	0.0003	0.0628
Echinococcus granulosus	biogenic amine 5HT receptor	0.0427	0.2048	0.2046
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0051	0.0048
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0015	0.0021	0.0018
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0074	0.0071
Brugia malayi	larval opioid receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	c src tyrosine kinase	0.0015	0.0021	0.0018
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0015	0.0021	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus granulosus	sex peptide receptor	0.0021	0.0051	0.0048
Brugia malayi	Hr1 repeat family protein	0.0026	0.0074	0.0071
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0051	0.0048
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.0051	0.0048
Schistosoma mansoni	protein kinase C mu	0.0013	0.0012	0.0008
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0021	0.0051	1
Brugia malayi	neuropeptide F receptor	0.0021	0.0051	0.0048
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0009	0.0006
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	Protein kinase C brain isozyme	0.0072	0.0302	0.0299
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0013	0.0012	0.0008
Loa Loa (eye worm)	SRC-1	0.0015	0.0021	0.002
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.0051	0.0048
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0051	0.005
Schistosoma mansoni	serine/threonine protein kinase	0.0172	0.0796	0.0793
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0012	0.0009	0.0008
Echinococcus granulosus	serine:threonine protein kinase N2	0.0026	0.0074	0.0071
Schistosoma mansoni	opsin-like receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.0051	0.0048
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0012	0.0008
Echinococcus granulosus	fmrfamide receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	serotonin receptor	0.0427	0.2048	0.2046
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0048	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0015	0.0021	0.0018
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0051	0.005
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Onchocerca volvulus		0.0021	0.0051	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Schistosoma mansoni	adenoreceptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0051	0.0048
Brugia malayi	STE20-like kinase MST	0.0227	0.1068	0.1065
Loa Loa (eye worm)	TK/ABL protein kinase	0.0011	0.0003	0.0002
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.0051	0.0048
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0029	0.0092	0.0664
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0026	0.0074	0.0071
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.0051	0.0048
Brugia malayi	Sex muscle abnormal protein 5	0.0012	0.0009	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0172	0.0796	0.0795
Echinococcus multilocularis	c src tyrosine kinase	0.0015	0.0021	0.0018
Schistosoma mansoni	vav2	0.0017	0.0031	0.0027
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0048	0.0184	0.0183
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Trypanosoma brucei	STE20-like serine/threonine-protein kinase 1, putative	0.0058	0.0233	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0051	0.0048
Echinococcus granulosus	orexin receptor type 2	0.0021	0.0051	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0184	0.3248
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0074	0.0763
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	serine:threonine protein kinase 3	0.0227	0.1068	0.1065
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0051	0.0048
Schistosoma mansoni	serine/threonine-protein kinase	0.0029	0.0092	0.0089
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	nervana 2	0.002	0.0048	0.0045
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.2043	1	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0027	0.0082	0.0079
Echinococcus granulosus	neuropeptide receptor A26	0.0021	0.0051	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0184	0.3248
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Brugia malayi	G-protein coupled receptor	0.0021	0.0051	0.0048
Brugia malayi	Serotonin receptor	0.0021	0.0051	0.0048
Brugia malayi	Tyrosine-protein kinase abl-1	0.0015	0.0021	0.0018
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0026	0.0074	0.0073
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0015	0.0021	0.0019
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Schistosoma mansoni	hypothetical protein	0.0021	0.0051	0.0048
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	amine GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	protein kinase c iota type	0.0031	0.0103	0.01
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0051	0.0048
Brugia malayi	Variant SH3 domain containing protein	0.0015	0.0021	0.0017
Schistosoma mansoni	amine GPCR	0.0021	0.0051	0.0048
Schistosoma mansoni	hypothetical protein	0.0021	0.0051	0.0048
Echinococcus multilocularis	RNA directed DNA polymerase	0.0039	0.0141	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0184	0.3248
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0051	0.0048
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0015	0.0021	0.0018
Echinococcus multilocularis	rac serine:threonine kinase	0.0029	0.0092	0.0089
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Trypanosoma cruzi	STE/STE20 serine/threonine-protein kinase, putative	0.0058	0.0233	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0051	0.0048
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0022	0.0055	0.0052
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0026	0.0074	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0184	0.3248
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0015	0.0021	0.0018
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0026	0.0074	0.0073
Onchocerca volvulus		0.0021	0.0051	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0015	0.0021	0.0018
Echinococcus multilocularis	myosin iiia	0.0058	0.0233	0.023
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0026	0.0074	0.0073
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0026	0.0074	0.0071
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0016	0.0025	0.0946
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0051	0.0048
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Echinococcus granulosus	growth factor receptor bound protein 2	0.0012	0.0009	0.0006
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0051	0.0048
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0051	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0074	0.0071
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0013	0.0012	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Giardia lamblia	Kinase, STE STE20	0.0058	0.0233	0.3765
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0026	0.0074	0.0071
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0026	0.0074	0.0073
Echinococcus granulosus	serine:threonine protein kinase 3	0.0227	0.1068	0.1065
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0051	0.005
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0051	0.0048
Schistosoma mansoni	hypothetical protein	0.0021	0.0051	0.0048
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0302	0.0299
Echinococcus granulosus	serotonin receptor	0.0021	0.0051	0.0048
Brugia malayi	GnHR receptor homolog	0.0021	0.0051	0.0048
Echinococcus granulosus	serine/threonine protein kinase	0.0029	0.0092	0.0089
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0015	0.0021	0.0018
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0012	0.0009	0.0006
Giardia lamblia	Kinase, NEK	0.0109	0.0482	1
Entamoeba histolytica	serine/threonine-protein kinase 3, putative	0.0058	0.0233	1
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0074	0.0071
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.0051	0.0048
Plasmodium falciparum	NIMA related kinase 1	0.0109	0.0482	1
Onchocerca volvulus		0.0021	0.0051	1
Entamoeba histolytica	protein kinase, putative	0.0016	0.0025	0.0946
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0074	0.0763
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0046	0.0174	0.0173
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0015	0.0021	0.0018
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.0427	0.2048	0.2047
Onchocerca volvulus		0.0021	0.0051	1
Onchocerca volvulus		0.0021	0.0051	1
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0051	0.0048
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.0051	0.0048
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.0051	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0172	0.0796	0.0793
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0015	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0013	0.0012	0.0008
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0051	0.0048
Onchocerca volvulus		0.0021	0.0051	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0026	0.0074	0.0071
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0015	0.0021	0.0018
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0012	0.0008
Echinococcus granulosus	allatostatin A receptor	0.0021	0.0051	0.0048
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0029	0.0092	0.387
Loa Loa (eye worm)	TK/FER protein kinase	0.0011	0.0003	0.0002
Brugia malayi	G-protein coupled receptor	0.0021	0.0051	0.0048
Brugia malayi	Serotonin receptor	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0013	0.0012	0.001
Echinococcus multilocularis	nervana 2	0.002	0.0048	0.0045
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.0051	0.0048
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0015	0.0021	0.0018
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0015	0.0021	0.0018
Trypanosoma cruzi	STE/STE20 serine/threonine-protein kinase, putative	0.0058	0.0233	1
Echinococcus granulosus	protein kinase c epsilon type	0.0033	0.0109	0.0106
Brugia malayi	SRC-1	0.0015	0.0021	0.0018
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0048
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.0051	0.0048
Brugia malayi	sulfakinin receptor protein	0.0021	0.0051	0.0048
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0051	0.005
Echinococcus granulosus	NDR protein kinase	0.0026	0.0074	0.0071
Schistosoma mansoni	serine/threonine kinase	0.0026	0.0074	0.0071
Echinococcus granulosus	protein kinase c iota type	0.0031	0.0103	0.01
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0051	0.0048
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.0051	0.0048
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0051	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1626711

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1472734