Detailed information for compound 1472746

Basic information

Technical information
  • TDR Targets ID: 1472746
  • Name: 6-ethyl-N-(furan-2-ylmethyl)thieno[3,2-e]pyri midin-4-amine
  • MW: 259.327 | Formula: C13H13N3OS
  • H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1sc2c(c1)c(ncn2)NCc1ccco1
  • InChi: 1S/C13H13N3OS/c1-2-10-6-11-12(15-8-16-13(11)18-10)14-7-9-4-3-5-17-9/h3-6,8H,2,7H2,1H3,(H,14,15,16)
  • InChiKey: OYNSHJODCUXKKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-ethyl-N-(2-furylmethyl)thieno[3,2-e]pyrimidin-4-amine
  • 6-ethyl-N-(2-furylmethyl)-4-thieno[3,2-e]pyrimidinamine
  • (6-ethylthieno[3,2-e]pyrimidin-4-yl)-(2-furylmethyl)amine
  • ZINC00187678
  • BAS 00287786
  • Oprea1_825105

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0104 0.0089
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0015 0.004 0.0025
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0015 0.004 0.0025
Brugia malayi Tyrosine-protein kinase abl-1 0.0015 0.004 0.0025
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.004 0.0208 0.0193
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1504 1 1
Giardia lamblia Kinase, NEK 0.0111 0.0678 1
Brugia malayi SRC-1 0.0015 0.004 0.0025
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0015 0.0039 0.0025
Echinococcus multilocularis RNA directed DNA polymerase 0.004 0.0208 0.0193
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0012 0.0016 0.0004
Echinococcus granulosus Protein kinase C brain isozyme 0.0073 0.0424 0.041
Echinococcus granulosus tyrosine protein kinase Fyn 0.0015 0.004 0.0025
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1504 1 1
Schistosoma mansoni nck2/grb4 0.0013 0.0023 0.0008
Schistosoma mansoni ste20-related kinase 0.0181 0.1148 0.1135
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0078 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0011
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0015 0.004 0.0025
Brugia malayi protein kinase C3,putative 0.0012 0.0016 0.0001
Echinococcus multilocularis tyrosine protein kinase Abl 0.0015 0.004 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0258 0.3133
Schistosoma mansoni serine/threonine kinase 0.0025 0.0104 0.0089
Brugia malayi RhoGAP domain containing protein 0.0015 0.0039 0.0025
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0234 0.15 0.149
Brugia malayi Protein kinase domain containing protein 0.0176 0.1118 0.1105
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0013 0.0023 0.0011
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0058 0.0327 1
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0258 0.3133
Schistosoma mansoni biogenic amine (5HT) receptor 0.0148 0.0927 0.0913
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0025 0.0104 0.0092
Onchocerca volvulus 0.0012 0.0015 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0249 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0104 0.0605
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0027 0.0115 0.0101
Echinococcus multilocularis N chimaerin 0.0015 0.0039 0.0025
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0025 0.0104 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0104 0.0089
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0047 0.0254 0.0242
Brugia malayi Hr1 repeat family protein 0.0025 0.0104 0.0089
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0104 0.0605
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0012 0.0016 0.0004
Entamoeba histolytica protein kinase, putative 0.0048 0.0258 0.7796
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.0039 0.0025
Echinococcus multilocularis protein kinase c epsilon type 0.0032 0.0154 0.0139
Brugia malayi Sex muscle abnormal protein 5 0.0013 0.0023 0.0008
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.0039 0.0025
Onchocerca volvulus 0.0012 0.0015 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0078 0.0063
Echinococcus granulosus N chimaerin 0.0015 0.0039 0.0025
Schistosoma mansoni amine GPCR 0.0199 0.127 0.1256
Brugia malayi Protein kinase c protein 2 0.0053 0.0295 0.0281
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.0129 0.0115
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0025 0.0104 0.0092
Echinococcus multilocularis serotonin receptor 0.0148 0.0927 0.0913
Echinococcus multilocularis serotonin receptor 0.0148 0.0927 0.0913
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0029 0.0129 0.0664
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0078 0.0063
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0058 0.0327 1
Schistosoma mansoni atypical protein kinase C 0.0031 0.0145 0.013
Onchocerca volvulus 0.0012 0.0015 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0015 0.004 0.0025
Echinococcus granulosus serine:threonine protein kinase 3 0.0234 0.15 0.1488
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0012 0.0016 0.0001
Brugia malayi Protein kinase domain containing protein 0.0025 0.0104 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0016 0.0001
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0021 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0258 0.3133
Loa Loa (eye worm) TK protein kinase 0.0012 0.0015 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0023 0.0008
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0025 0.0104 0.0089
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0021 0.0006
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0012 0.0016 0.0001
Schistosoma mansoni tyrosine kinase 0.0015 0.004 0.0025
Trypanosoma cruzi Protein kinase B 0.0029 0.0129 0.0664
Brugia malayi p70 ribosomal S6 kinase beta 0.0046 0.0244 0.023
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0012 0.0016 0.0001
Schistosoma mansoni adapter molecule crk 0.0013 0.0023 0.0008
Entamoeba histolytica protein kinase, putative 0.0046 0.0244 0.7346
Echinococcus multilocularis serine:threonine protein kinase 38 0.0025 0.0104 0.0089
Onchocerca volvulus 0.0012 0.0015 1
Schistosoma mansoni tyrosine kinase 0.0015 0.004 0.0025
Brugia malayi STE20-like kinase MST 0.0234 0.15 0.1488
Echinococcus multilocularis myosin iiia 0.0058 0.0327 0.0313
Entamoeba histolytica protein kinase, putative 0.0015 0.0035 0.0644
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0015 0.0039 0.0025
Plasmodium falciparum NIMA related kinase 1 0.0111 0.0678 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0025 0.0104 0.0092
Loa Loa (eye worm) hypothetical protein 0.0025 0.0104 0.0092
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0111 0.0678 1
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0023 0.0008
Brugia malayi Protein kinase domain containing protein 0.0025 0.0104 0.0089
Echinococcus granulosus nervana 2 0.0021 0.0078 0.0063
Schistosoma mansoni tyrosine kinase 0.0015 0.004 0.0025
Trichomonas vaginalis STE family protein kinase 0.0058 0.0327 0.4259
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0032 0.0154 0.0142
Onchocerca volvulus 0.0012 0.0015 1
Echinococcus granulosus serine/threonine protein kinase 0.0029 0.0129 0.0115
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0015 0.004 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0678 1
Echinococcus granulosus NCK adaptor protein 0.0013 0.0023 0.0008
Echinococcus multilocularis NCK adaptor protein 0.0013 0.0023 0.0008
Onchocerca volvulus 0.0012 0.0015 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0424 0.041
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0111 0.0678 1
Echinococcus granulosus protein kinase C gamma type 0.0066 0.0383 0.0368
Entamoeba histolytica protein kinase, putative 0.0025 0.0104 0.2847
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0013 0.0023 0.0008
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0015 0.004 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.0129 0.0115
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0023 0.0008
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.0104 0.0089
Entamoeba histolytica protein kinase, putative 0.0048 0.0258 0.7796
Schistosoma mansoni tyrosine kinase 0.0015 0.004 0.0025
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0015 0.0035 0.0644
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0104 0.0605
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0027 0.0115 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0118 0.0835
Brugia malayi C1-like domain containing protein 0.0012 0.0016 0.0001
Echinococcus multilocularis nervana 2 0.0021 0.0078 0.0063
Echinococcus granulosus nervana 2 0.0021 0.0078 0.0063
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0015 0.004 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0154 0.0139
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0258 0.3133
Brugia malayi Protein kinase domain containing protein 0.0048 0.0258 0.0244
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0058 0.0327 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0078 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0148 0.0927 0.0916
Loa Loa (eye worm) AGC/NDR protein kinase 0.0025 0.0104 0.0092
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Echinococcus granulosus biogenic amine 5HT receptor 0.0148 0.0927 0.0913
Echinococcus multilocularis growth factor receptor bound protein 2 0.0013 0.0023 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0148 0.0927 0.0916
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0015 0.004 0.0025
Echinococcus granulosus tyrosine protein kinase Fyn 0.0015 0.004 0.0025
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0046 0.0244 0.0232
Loa Loa (eye worm) TK/ABL protein kinase 0.0012 0.0015 0.0003
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0129 0.3665
Loa Loa (eye worm) AGC/AKT protein kinase 0.0048 0.0258 0.0247
Echinococcus multilocularis protein kinase c iota type 0.0031 0.0145 0.013
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0129 0.3665
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0176 0.1118 0.1108
Echinococcus multilocularis nervana 2 0.0021 0.0078 0.0063
Echinococcus granulosus NDR protein kinase 0.0025 0.0104 0.0089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0003
Loa Loa (eye worm) SRC-1 0.0015 0.004 0.0028
Giardia lamblia Kinase, NEK 0.0111 0.0678 1
Echinococcus granulosus protein kinase c iota type 0.0031 0.0145 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0424 0.041
Echinococcus multilocularis serine threonine protein kinase 0.0066 0.0383 0.0368
Trichomonas vaginalis STE family protein kinase 0.0111 0.0678 1
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1504 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0015 0.004 0.0025
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0073 0.0424 0.041
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0058 0.0327 1
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Echinococcus granulosus growth factor receptor bound protein 2 0.0013 0.0023 0.0008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0015 0.004 0.0025
Echinococcus granulosus protein kinase c epsilon type 0.0032 0.0154 0.0139
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0023 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1118 0.1105
Leishmania major protein kinase, putative 0.0058 0.0327 0.5
Schistosoma mansoni serine/threonine protein kinase 0.1504 1 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0025 0.0104 0.0089
Echinococcus multilocularis rac serine:threonine kinase 0.0029 0.0129 0.0115
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0025 0.0104 0.0089
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0258 0.3133
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0015 0.004 0.0025
Brugia malayi protein kinase C II. 0.0032 0.0154 0.0139
Echinococcus granulosus tyrosine protein kinase Lyn 0.0021 0.0077 0.0062
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0015 0.004 0.0025
Echinococcus granulosus RNA directed DNA polymerase 0.004 0.0208 0.0193
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0025 0.0104 0.0089
Echinococcus granulosus tyrosine protein kinase Fyn 0.0015 0.004 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0104 0.0089
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0025 0.0104 0.0092
Entamoeba histolytica protein kinase 2, putative 0.0027 0.0115 0.3215
Echinococcus multilocularis serine:threonine protein kinase 3 0.0234 0.15 0.1488
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0025 0.0104 0.0089
Brugia malayi Protein kinase domain containing protein 0.0012 0.0016 0.0001
Schistosoma mansoni protein kinase C mu 0.0012 0.0016 0.0001
Schistosoma mansoni vav2 0.0017 0.0054 0.0039
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0015 0.004 0.0025
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0058 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0208 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0016 0.0001
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0039 0.0025
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.0104 0.0089
Giardia lamblia Kinase, NEK 0.0111 0.0678 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0027 0.0115 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0258 0.3133
Echinococcus granulosus c src tyrosine kinase 0.0015 0.004 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0023 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0104 0.0089
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0015 0.0003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0015 0.004 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0258 0.3133
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0025 0.0104 0.0089
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0015 0.0039 0.0027
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0015 0.004 0.0025
Echinococcus multilocularis c src tyrosine kinase 0.0015 0.004 0.0025
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0015 0.004 0.0025
Giardia lamblia Kinase, STE STE20 0.0058 0.0327 0.3765

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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