TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 426.508 | Formula: C24H27O3PS
H donors: 0 H acceptors: 2 LogP: 5.3 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCc2c1ccc(c2)OP(=O)(c1ccccc1)S
InChi: 1S/C24H27O3PS/c1-24-14-13-20-19-10-8-17(27-28(26,29)18-5-3-2-4-6-18)15-16(19)7-9-21(20)22(24)11-12-23(24)25/h2-6,8,10,15,20-22H,7,9,11-14H2,1H3,(H,26,29)/t20-,21-,22+,24+,28?/m1/s1
InChiKey: ZWZDPZGIKLMPPQ-HPQXBILDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0125	0.0207
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0328	0.0512
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Schistosoma mansoni	hypothetical protein	0.0164	0.1182	0.1182
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0328	0.0508
Echinococcus multilocularis	neuropeptide s receptor	0.0037	0.0125	0.0207
Echinococcus granulosus	p2X purinoceptor 4	0.0066	0.0365	0.0602
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.0125	0.0207
Brugia malayi	neuropeptide F receptor	0.0037	0.0125	0.0176
Toxoplasma gondii	RNA-directed DNA polymerase	0.0083	0.0514	1
Schistosoma mansoni	amine GPCR	0.0037	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	g-protein coupled receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0037	0.0125	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0116	0.1917
Brugia malayi	Telomerase reverse transcriptase	0.0222	0.1668	0.273
Brugia malayi	Dopamine receptor	0.0037	0.0125	0.0176
Schistosoma mansoni	biogenic amine (5HT) receptor	0.047	0.3733	0.3733
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0125	0.0125
Brugia malayi	larval opioid receptor	0.0037	0.0125	0.0176
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0083	0.0514	1
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.0125	0.0207
Schistosoma mansoni	amine GPCR	0.0037	0.0125	0.0125
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.0125	0.0207
Echinococcus multilocularis	p2X purinoceptor 4	0.0066	0.0365	0.0602
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0125	0.0207
Brugia malayi	Dopamine receptor protein 1	0.0037	0.0125	0.0176
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0116	0.0191
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0037	0.0125	0.0125
Brugia malayi	ORL1-like opioid receptor	0.0037	0.0125	0.0176
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0037	0.0125	0.0207
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Echinococcus multilocularis	serotonin receptor	0.047	0.3733	0.6162
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0037	0.0125	0.0172
Schistosoma mansoni	histamine h1 receptor	0.0037	0.0125	0.0125
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0037	0.0125	0.0125
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.0125	0.0207
Brugia malayi	hypothetical protein	0.0024	0.0021	0.0004
Schistosoma mansoni	amine GPCR	0.0037	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Schistosoma mansoni	neuropeptide f receptor 76f	0.0037	0.0125	0.0125
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Schistosoma mansoni	amine GPCR	0.0037	0.0125	0.0125
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0037	0.0125	0.0125
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0749	0.6059	1
Brugia malayi	TAR-binding protein	0.0061	0.0328	0.0512
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.0125	0.0125
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	allatostatin A receptor	0.0037	0.0125	0.0207
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0116	0.5
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0116	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0125	0.0125
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.0125	0.0207
Echinococcus granulosus	sex peptide receptor	0.0037	0.0125	0.0207
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0116	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0306	0.2363	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.0125	0.0172
Brugia malayi	Bromodomain containing protein	0.0037	0.0127	0.0178
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0116	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0328	0.0328
Echinococcus multilocularis	sex peptide receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	inositol-1	0.0036	0.0116	0.0156
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.0125
Brugia malayi	Dopamine receptor protein 2	0.0037	0.0125	0.0176
Brugia malayi	Inositol-1	0.0036	0.0116	0.016
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.0125	0.0207
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0116	0.1917
Schistosoma mansoni	adenoreceptor	0.0037	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0125	0.0125
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0037	0.0125	0.0207
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.047	0.3733	0.6148
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0125	0.0207
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.0125	0.0125
Brugia malayi	sulfakinin receptor protein	0.0037	0.0125	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	geminin	0.0164	0.1182	0.1951
Trypanosoma brucei	telomerase reverse transcriptase	0.0083	0.0514	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0125	0.0207
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	orexin receptor type 2	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0388	0.0607
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0328	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0328	0.0328
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Echinococcus multilocularis	p2X purinoceptor 4	0.0066	0.0365	0.0602
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0037	0.0125	0.0176
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0085	0.5
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0125	0.0207
Echinococcus multilocularis	geminin	0.0164	0.1182	0.1951
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0125	0.0125
Brugia malayi	RE15519p	0.0037	0.0125	0.0176
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.0125	0.0207
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.0125	0.0207
Echinococcus granulosus	allatostatin A receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	neuropeptide receptor A26	0.0037	0.0125	0.0207
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0328	0.0328
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.0125	0.0172
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0116	0.1917
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0328	0.0508
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0037	0.0125	0.0176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.0125	0.0207
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.0125	0.0207
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.0125	0.0207
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.0125	0.0207
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0328	0.0328
Brugia malayi	G-protein coupled receptor	0.0037	0.0125	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	fmrfamide receptor	0.0037	0.0125	0.0207
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0328	0.0542
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.0125	0.0172
Brugia malayi	follicle stimulating hormone receptor	0.0037	0.0125	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	neuropeptide s receptor	0.0037	0.0125	0.0207
Echinococcus granulosus	somatostatin receptor	0.0037	0.0125	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0037	0.0125	0.0172
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.0125	0.0125
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0116	0.1917
Brugia malayi	Serotonin receptor	0.0037	0.0125	0.0176
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0116	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Brugia malayi	map kinase activated protein kinase protein 2	0.0749	0.6059	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0162	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0116	0.0191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Loa Loa (eye worm)	TYRA-2 protein	0.0037	0.0125	0.0172
Brugia malayi	Bromodomain containing protein	0.0072	0.0422	0.0667
Brugia malayi	putative neuropeptide receptor	0.0037	0.0125	0.0176
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0125	0.0125
Echinococcus granulosus	p2X purinoceptor 4	0.0066	0.0365	0.0602
Echinococcus multilocularis	p2X purinoceptor 4	0.0066	0.0365	0.0602
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	serotonin receptor	0.047	0.3733	0.6162
Echinococcus granulosus	dro:myosuppressin receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0037	0.0125	0.0172
Brugia malayi	AKH receptor	0.0037	0.0125	0.0176
Echinococcus granulosus	g-protein coupled receptor	0.0037	0.0125	0.0207
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0037	0.0125	0.0176
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Echinococcus multilocularis	dro:myosuppressin receptor	0.0037	0.0125	0.0207
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Echinococcus granulosus	biogenic amine 5HT receptor	0.047	0.3733	0.6162
Schistosoma mansoni	myosin xvIII	0.0037	0.0125	0.0125
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0037	0.0125	0.0207
Schistosoma mansoni	opsin-like receptor	0.0037	0.0125	0.0125
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.0125	0.0207
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0037	0.0125	0.0207
Schistosoma mansoni	growth hormone secretagogue receptor	0.0037	0.0125	0.0125
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0037	0.0125	0.0207
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0037	0.0125	0.0125
Echinococcus granulosus	hypothetical protein	0.0037	0.0125	0.0207
Brugia malayi	G protein-coupled receptor	0.0037	0.0125	0.0176
Echinococcus granulosus	p2X purinoceptor 4	0.0066	0.0365	0.0602
Brugia malayi	neuropeptide F receptor	0.0037	0.0125	0.0176
Schistosoma mansoni	P2X receptor subunit	0.0066	0.0365	0.0365
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0037	0.0125	0.0125
Schistosoma mansoni	P2X receptor subunit	0.0066	0.0365	0.0365
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0127	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0037	0.0125	0.0176
Brugia malayi	Serotonin receptor	0.0037	0.0125	0.0176
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0328	0.0542
Brugia malayi	GnHR receptor homolog	0.0037	0.0125	0.0176
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0108	0.0178
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.0125	0.0125
Leishmania major	telomerase reverse transcriptase, putative	0.0083	0.0514	1
Brugia malayi	RNA binding protein	0.0061	0.0328	0.0512
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0125	0.0125
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0085	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0125	0.0207
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0116	0.1917
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0037	0.0125	0.0176
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0125	0.0125
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0037	0.0125	0.0207
Echinococcus granulosus	neuropeptide FF receptor 2	0.0037	0.0125	0.0207
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0037	0.0125	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	7tm_1 domain containing protein	0.0037	0.0125	0.0207
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0037	0.0125	0.0125
Schistosoma mansoni	P2X receptor subunit	0.0066	0.0365	0.0365
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0116	0.5
Schistosoma mansoni	opsin-like receptor	0.0037	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	orexin receptor type 2	0.0037	0.0125	0.0207
Schistosoma mansoni	serine/threonine protein kinase	0.0749	0.6059	0.6059
Echinococcus granulosus	serotonin receptor	0.0037	0.0125	0.0207
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Loa Loa (eye worm)	hypothetical protein	0.047	0.3733	0.6148
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0125	0.0125
Plasmodium falciparum	telomerase reverse transcriptase	0.0083	0.0514	1
Schistosoma mansoni	bromodomain containing protein	0.0061	0.0328	0.0328
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0125	0.0207
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	neuropeptide receptor	0.0037	0.0125	0.0207
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0125	0.0125
Loa Loa (eye worm)	melatonin receptor type 1A	0.0037	0.0125	0.0172
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.0125	0.0125
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.0125
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0037	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0328	0.0328
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.0125	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Schistosoma mansoni	opsin-like receptor	0.0037	0.0125	0.0125
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0037	0.0125	0.0207
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0749	0.6059	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0037	0.0125	0.0207
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Schistosoma mansoni	hypothetical protein	0.0037	0.0125	0.0125
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0125	0.0207
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0037	0.0125	0.0207
Brugia malayi	putative neuropeptide receptor NPR1	0.0037	0.0125	0.0176
Echinococcus granulosus	G protein coupled receptor 139	0.0037	0.0125	0.0207
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0083	0.0514	1
Brugia malayi	Melatonin receptor type 1A	0.0037	0.0125	0.0176
Echinococcus granulosus	neuropeptide receptor A26	0.0037	0.0125	0.0207
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0037	0.0125	0.0207
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.0125	0.0172
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0083	0.0514	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0037	0.0125	0.0176
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0037	0.0125	0.0125
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0125	0.0125
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0108	0.0178
Schistosoma mansoni	P2X receptor subunit	0.0066	0.0365	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0146	0.0207
Brugia malayi	G-protein coupled receptor	0.0037	0.0125	0.0176
Schistosoma mansoni	hypothetical protein	0.0164	0.1182	0.1182
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0125	0.0207
Echinococcus multilocularis	somatostatin receptor	0.0037	0.0125	0.0207
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0116	0.0116
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0037	0.0125	0.0172
Echinococcus granulosus	7TM GPCR rhodopsin	0.0037	0.0125	0.0207
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0116	0.5
Brugia malayi	hypothetical protein	0.0037	0.0125	0.0176
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0749	0.6059	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0037	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0125	0.0172
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.0125	0.0207
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0037	0.0125	0.0172
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0299	0.0493
Echinococcus granulosus	neuropeptide receptor	0.0037	0.0125	0.0207
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0125	0.0125
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0299	0.0493
Echinococcus multilocularis	G protein coupled receptor 139	0.0037	0.0125	0.0207
Giardia lamblia	Telomerase catalytic subunit	0.0083	0.0514	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0125	0.0207

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 42 %	Inhibition of estrone sulfatase at 10 microM in intact MCF-7 cells	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1628119

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1472750