Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.3175 | 0.3175 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2814 | 0.2814 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.054 | 1 | 1 |
Leishmania major | ion transport protein-like protein | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0281 | 1 | |
Toxoplasma gondii | ion channel protein | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0281 | 0.0281 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0281 | 0.0281 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0281 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0281 | 0.0281 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0281 | 0.0281 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0349 | 0.6331 | 0.6331 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0281 | 0.0281 |
Plasmodium falciparum | potassium channel | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0281 | 0.0281 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0018 | 0 | 0.5 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.054 | 1 | 1 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0018 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0281 | 0.0281 |
Mycobacterium ulcerans | ion transport protein | 0.0018 | 0 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 1 | 1 |
Plasmodium vivax | potassium channel, putative | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0018 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0281 | 0.0281 |
Plasmodium falciparum | potassium channel | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0281 | 0.0281 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0018 | 0 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0281 | 1 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0281 | 0.0281 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.027 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.2985 | 0.2985 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0281 | 0.0281 |
Trypanosoma cruzi | ion transport protein, putative | 0.0018 | 0 | 0.5 |
Plasmodium vivax | potassium channel, putative | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0281 | 1 | |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0018 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.