Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0524 | 0.1944 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0048 | 0.0081 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.002 | 0.0073 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.1599 | 0.5715 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.019 | 0.2696 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.2294 | 0.2279 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0524 | 0.1944 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0048 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0178 | 0.066 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0524 | 0.1944 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0545 | 0.2894 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 0.0926 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0137 | 0.0584 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0545 | 0.5056 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0137 | 0.0508 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0944 | 1 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0185 | 0.0687 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0137 | 0.0335 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0132 | 0.1799 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0137 | 0.0335 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0137 | 0.0508 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2294 | 0.2279 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0944 | 0.35 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.019 | 0.2696 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.002 | 0.0073 |
Onchocerca volvulus | 0.0026 | 0.0185 | 0.0189 | |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0944 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0137 | 0.0508 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.019 | 0.2696 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0944 | 0.0926 |
Leishmania major | hypothetical protein, conserved | 0.0059 | 0.0683 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0137 | 0.0335 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0026 | 0.0185 | 0.1526 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0059 | 0.0683 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.019 | 0.2696 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0137 | 0.0335 |
Brugia malayi | hypothetical protein | 0.0119 | 0.1599 | 0.5933 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 0.3381 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0137 | 0.0335 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0185 | 0.0166 |
Echinococcus granulosus | lamin | 0.0026 | 0.0185 | 0.0166 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0185 | 0.0687 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.019 | 0.2696 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0185 | 0.0687 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0291 | 0.1078 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.019 | 0.2696 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0669 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2294 | 0.2279 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0545 | 0.2894 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.019 | 0.2696 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.019 | 0.2696 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.002 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0048 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0048 | 0.0179 |
Onchocerca volvulus | 0.019 | 0.2696 | 1 | |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 0.3381 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0185 | 0.0166 |
Schistosoma mansoni | lamin | 0.0026 | 0.0185 | 0.0166 |
Onchocerca volvulus | 0.0026 | 0.0185 | 0.0189 | |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0137 | 0.0508 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.019 | 0.2696 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0137 | 0.0335 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.002 | 0.0073 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0137 | 0.0508 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0137 | 0.0584 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 0.0926 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0185 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0291 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0048 | 0.0179 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0185 | 0.0166 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 0.0683 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0545 | 0.0526 |
Echinococcus multilocularis | geminin | 0.0164 | 0.2294 | 0.2279 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.019 | 0.2696 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0545 | 0.0526 |
Schistosoma mansoni | lamin | 0.0026 | 0.0185 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1599 | 0.5933 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0185 | 0.0687 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 0.0683 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1599 | 0.5933 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0944 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.1599 | 0.5715 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0137 | 0.0508 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0944 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0185 | 0.1526 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0524 | 0.1944 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0137 | 0.0335 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0944 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0669 | 1 | 1 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0026 | 0.0185 | 0.0593 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0137 | 0.0335 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.019 | 0.2696 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0291 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0048 | 0.0179 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0944 | 0.35 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0185 | 0.0166 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0185 | 0.0166 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.019 | 0.2696 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0185 | 0.0687 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.