TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 502.648 | Formula: C30H38N4O3
H donors: 3 H acceptors: 3 LogP: 4.41 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: NCc1ccc(cc1)c1nc2ccccc2c(c1)C(=O)NC[C@@H]1CC[C@H](CC1)CNC(=O)OC(C)(C)C
InChi: 1S/C30H38N4O3/c1-30(2,3)37-29(36)33-19-22-10-8-21(9-11-22)18-32-28(35)25-16-27(23-14-12-20(17-31)13-15-23)34-26-7-5-4-6-24(25)26/h4-7,12-16,21-22H,8-11,17-19,31H2,1-3H3,(H,32,35)(H,33,36)/t21-,22-
InChiKey: XMVDERVZJOZBTJ-HZCBDIJESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	acetyl-CoA carboxylase alpha	Starlite/ChEMBL	References
Homo sapiens	acetyl-CoA carboxylase beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium yoelii	acetyl-CoA carboxylase 1 precursor-related	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania mexicana	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Brugia malayi	Carboxyl transferase domain containing protein	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma congolense	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Toxoplasma gondii	acetyl-coA carboxylase ACC2	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	Acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	ko:K01961 acetyl-CoA carboxylase [EC6.4.1.2], putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	ko:K01946 biotin carboxylase [EC6.3.4.14], putative	Get druggable targets OG5_127493	All targets in OG5_127493
Cryptosporidium hominis	acetyl-CoA carboxylase 2	Get druggable targets OG5_127493	All targets in OG5_127493
Cryptosporidium parvum	acetyl-CoA carboxylase like biotin dependent carboxylase involved in fatty acid biosynthesis	Get druggable targets OG5_127493	All targets in OG5_127493
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	Get druggable targets OG5_127493	All targets in OG5_127493
Candida albicans	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania donovani	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium berghei	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania infantum	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Neospora caninum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma brucei gambiense	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania braziliensis	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma mansoni	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium knowlesi	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma cruzi	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	Get druggable targets OG5_127493	All targets in OG5_127493
Neospora caninum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	Acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma congolense	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania major	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma brucei	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0739	0.3223	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.2144	1	1
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0302	0.1118	0.6504
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0423	0.17	0.1671
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0302	0.1118	0.2932
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0423	0.17	0.4886
Leishmania major	acetyl-CoA carboxylase, putative	0.0203	0.0639	0.3633
Leishmania major	hypothetical protein, conserved	0.0302	0.1118	0.6504
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0423	0.17	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0302	0.1118	0.1087
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0302	0.1118	0.2932
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	0.6504
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0302	0.1118	0.0895
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0121	0.0244	0.1211
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	0.6504
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0302	0.1118	0.1087
Trypanosoma cruzi	acetyl-CoA carboxylase	0.0126	0.0267	0.1398
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	0.2932
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0302	0.1118	0.1087
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0302	0.1118	0.0645
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0302	0.1118	0.1087
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0423	0.17	0.4886
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0302	0.1118	1
Trichomonas vaginalis	conserved hypothetical protein	0.0739	0.3223	1
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0302	0.1118	0.1087
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0423	0.17	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.1118	0.6504
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0302	0.1118	0.6504
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0423	0.17	0.4886
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0302	0.1118	0.6504
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0423	0.17	0.4886
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0302	0.1118	0.0645
Loa Loa (eye worm)	hypothetical protein	0.1137	0.5144	0.5023
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0302	0.1118	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0302	0.1118	0.0895
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0302	0.1118	0.0645
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.1137	0.5144	0.5718
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	0.2932
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0302	0.1118	0.6504
Trichomonas vaginalis	conserved hypothetical protein	0.0302	0.1118	0.2932
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0302	0.1118	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0423	0.17	0.4886
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0302	0.1118	0.6504
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0302	0.1118	0.6504
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0302	0.1118	0.1087
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.1842	0.8544	1
Schistosoma mansoni	acetyl-CoA carboxylase	0.0203	0.0639	0.0607
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.1118	0.6504
Trypanosoma brucei	acetyl-CoA carboxylase	0.0203	0.0639	0.3633
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.1118	0.6504
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0302	0.1118	0.1087
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Trichomonas vaginalis	conserved hypothetical protein	0.0302	0.1118	0.2932
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0302	0.1118	0.0895
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0423	0.17	0.4886
Plasmodium vivax	phosphodiesterase gamma, putative	0.0302	0.1118	1
Toxoplasma gondii	hypothetical protein	0.0121	0.0244	0.0211
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.1118	0.6504
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0302	0.1118	0.2932
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.1137	0.5144	0.5128
Mycobacterium leprae	conserved hypothetical protein	0.0121	0.0244	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0302	0.1118	0.0645
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Toxoplasma gondii	hypothetical protein	0.0121	0.0244	0.0211
Toxoplasma gondii	hypothetical protein	0.0121	0.0244	0.0211
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0423	0.17	0.1671
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0302	0.1118	0.1087
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.1118	0.6504
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0618	0.2641	0.8046
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.0196	0.0605	0.037
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	0.2932
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0302	0.1118	0.1087
Loa Loa (eye worm)	PDE1B protein	0.0302	0.1118	0.0895
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0423	0.17	0.1671
Plasmodium falciparum	phosphodiesterase delta, putative	0.0302	0.1118	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.1842	0.8544	0.8539
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Mycobacterium ulcerans	putative regulatory protein	0.0121	0.0244	0.1211
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0739	0.3223	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.2144	1	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0423	0.17	0.4886
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0423	0.17	0.4886
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	0.2932
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0316	0.1186	0.6641
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0423	0.17	0.1379
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0147	0.0369	0.1433
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0302	0.1118	0.2932
Chlamydia trachomatis	biotin carboxylase	0.007	0	0.5
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0302	0.1118	0.2932
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.2144	1	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0423	0.17	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.2144	1	1
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.1842	0.8544	0.8508
Leishmania major	hypothetical protein, conserved	0.0316	0.1186	0.6912
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.2144	1	1
Mycobacterium ulcerans	putative regulatory protein	0.0121	0.0244	0.1211
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0302	0.1118	0.6504
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.0203	0.0639	0.0607
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0302	0.1118	0.6504
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0302	0.1118	0.6504
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.1842	0.8544	0.8539
Toxoplasma gondii	GAF domain-containing protein	0.0121	0.0244	0.0211
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0739	0.3223	1
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0302	0.1118	0.1087
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0302	0.1118	0.1087
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0147	0.0369	0.1433
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0302	0.1118	0.1087
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Trypanosoma cruzi	hypothetical protein, conserved	0.0302	0.1118	0.6504
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Leishmania major	hypothetical protein, conserved	0.0302	0.1118	0.6504
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0302	0.1118	0.2932
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0423	0.17	0.4886
Trypanosoma brucei	hypothetical protein, conserved	0.0302	0.1118	0.6504
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0302	0.1118	0.1087
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0316	0.1186	0.6912
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0302	0.1118	0.1087
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0423	0.17	0.4886
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0423	0.17	0.1671
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.0203	0.0639	0.0607
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0618	0.2641	0.8046
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0423	0.17	0.1671
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0077	0.0034	0.5
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.2144	1	1
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.0203	0.0639	0.0607
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0437	0.1768	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0423	0.17	0.4886
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0437	0.1768	1
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0302	0.1118	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0302	0.1118	0.1087
Loa Loa (eye worm)	hypothetical protein	0.2144	1	1
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	0.0203	0.0639	0.0607
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0302	0.1118	0.1087
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0302	0.1118	1
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0316	0.1186	0.6912
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0423	0.17	1
Trypanosoma brucei	GAF domain/TIP41-like family, putative	0.0316	0.1186	0.6912
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0423	0.17	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.33 uM	Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins measured after 1.5 hrs by Malachite green reagent method	ChEMBL.	21515056
IC50 (binding)	= 1.7 uM	Inhibition of human recombinant his-tagged ACC1 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins measured after 1.5 hrs by Malachite green reagent method	ChEMBL.	21515056

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1615283

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1475270