Detailed information for compound 1475750

Basic information

Technical information
  • TDR Targets ID: 1475750
  • Name: 4-[2,5-dimethyl-1-(2-phenylethyl)pyrrol-3-yl] -1,3-thiazol-2-amine
  • MW: 297.418 | Formula: C17H19N3S
  • H donors: 1 H acceptors: 1 LogP: 3.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1scc(n1)c1cc(n(c1C)CCc1ccccc1)C
  • InChi: 1S/C17H19N3S/c1-12-10-15(16-11-21-17(18)19-16)13(2)20(12)9-8-14-6-4-3-5-7-14/h3-7,10-11H,8-9H2,1-2H3,(H2,18,19)
  • InChiKey: RFEIFPRNCTUAPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[2,5-dimethyl-1-(2-phenylethyl)pyrrol-3-yl]thiazol-2-amine
  • 4-[2,5-dimethyl-1-(2-phenylethyl)-3-pyrrolyl]-2-thiazolamine
  • [4-[2,5-dimethyl-1-(2-phenylethyl)pyrrol-3-yl]thiazol-2-yl]amine
  • ZINC03888734

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0067 0 0.5
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.1091 1 1
Leishmania major hypothetical protein, conserved 0.0067 0 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0164 0.0948 0.0948
Loa Loa (eye worm) loechrig isoform VII 0.1091 1 1
Mycobacterium tuberculosis Conserved protein 0.0067 0 0.5
Echinococcus granulosus ankyrin repeat protein 0.0161 0.0916 0.0916
Toxoplasma gondii CBS domain-containing protein 0.0067 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0067 0 0.5
Toxoplasma gondii CBS domain-containing protein 0.0067 0 0.5
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0067 0 0.5
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.1091 1 1
Mycobacterium tuberculosis Conserved protein 0.0067 0 0.5
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0067 0 0.5
Trypanosoma cruzi GMP reductase 0.0067 0 0.5
Mycobacterium ulcerans cystathionine beta-synthase 0.0067 0 0.5
Trypanosoma cruzi chloride channel protein, putative 0.0067 0 0.5
Leishmania major guanosine monophosphate reductase 0.0067 0 0.5
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0067 0 0.5
Schistosoma mansoni protein kinase subunit gamma 0.1091 1 1
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0067 0 0.5
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0067 0 0.5
Trypanosoma brucei GMP reductase 0.0067 0 0.5
Onchocerca volvulus 0.0067 0 0.5
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0067 0 0.5
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0067 0 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0161 0.0916 0.0916
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0067 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0067 0 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0164 0.0948 0.0948
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0067 0 0.5
Mycobacterium leprae conserved hypothetical protein 0.0067 0 0.5
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0067 0 0.5
Chlamydia trachomatis Mg++ transporter 0.0067 0 0.5
Plasmodium falciparum protein MAM3, putative 0.0067 0 0.5
Leishmania major chloride channel protein, putative 0.0067 0 0.5
Mycobacterium tuberculosis Conserved protein 0.0067 0 0.5
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.1023 0.934 0.934
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0067 0 0.5
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0067 0 0.5
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0067 0 0.5
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0067 0 0.5
Trypanosoma cruzi chloride channel protein, putative 0.0067 0 0.5
Trypanosoma cruzi chloride channel protein, putative 0.0067 0 0.5
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0067 0 0.5
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0067 0 0.5
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0067 0 0.5
Echinococcus multilocularis ankyrin repeat protein 0.0161 0.0916 0.0916
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0067 0 0.5
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0067 0 0.5
Trypanosoma cruzi chloride channel protein, putative 0.0067 0 0.5
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.1091 1 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0067 0 0.5
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0067 0 0.5
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0067 0 0.5
Mycobacterium ulcerans transcriptional regulator 0.0067 0 0.5
Treponema pallidum hemolysin (tlyC) 0.0067 0 0.5
Treponema pallidum Mg2+ transport protein (mgtE) 0.0067 0 0.5
Leishmania major CBS domain protein, conserved 0.0067 0 0.5
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0067 0 0.5
Leishmania major chloride channel protein, putative 0.0067 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0067 0 0.5
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0067 0 0.5
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0067 0 0.5
Chlamydia trachomatis CBS domain-containing protein 0.0067 0 0.5
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0067 0 0.5
Toxoplasma gondii IMP dehydrogenas 0.0067 0 0.5
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0067 0 0.5
Toxoplasma gondii CBS family protein 0.0067 0 0.5
Trypanosoma cruzi GMP reductase 0.0067 0 0.5
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0067 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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