Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium release activated calcium channel | 0.2262 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0327 | 0.0327 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0327 | 0.0327 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0001 | 0.0001 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0003 | 0.0001 | 0.0001 |
Brugia malayi | olfactory channel protein osm-9 | 0.0083 | 0.0355 | 0.0028 |
Echinococcus granulosus | calcium release activated calcium channel | 0.2262 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.0001 | 0.0001 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.2262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0355 | 0.0355 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0327 | 0.0327 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0003 | 0.0001 | 0.0001 |
Schistosoma mansoni | Protein orai-1 | 0.2262 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.0001 | 0.0001 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0327 | 0.0327 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0327 | 0.0327 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0327 | 0.0327 |
Schistosoma mansoni | Protein orai-1 | 0.2262 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0327 | 0.0327 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.