Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0033 | 0.0333 | 0.0642 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.03 | 0.0293 |
Brugia malayi | hypothetical protein | 0.0016 | 0.012 | 0.0997 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.0603 | 0.0674 |
Schistosoma mansoni | hypothetical protein | 0.0405 | 0.5068 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0304 | 0.3794 | 1 |
Onchocerca volvulus | 0.0033 | 0.0333 | 1 | |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0458 | 0.575 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.014 | 0.1211 |
Echinococcus multilocularis | snurportin 1 | 0.0304 | 0.3794 | 0.3789 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0405 | 0.5068 | 0.5064 |
Echinococcus granulosus | snurportin 1 | 0.0304 | 0.3794 | 0.7482 |
Echinococcus granulosus | dnaJ subfamily B | 0.0405 | 0.5068 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0333 | 0.0804 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.2443 | 0.4812 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0212 | 1 |
Onchocerca volvulus | 0.0033 | 0.0333 | 1 | |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0281 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0281 | 0.0667 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0281 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0118 | 0.0234 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0333 | 0.0325 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0281 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0111 | 0.0214 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.003 | 0.0022 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0231 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0333 | 0.0325 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.028 | 0.0663 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0212 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0333 | 0.0642 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0281 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.3794 | 0.7482 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0212 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0333 | 0.3299 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0059 | 0.01 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0333 | 0.3299 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0333 | 0.0642 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.028 | 0.2724 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0333 | 0.0804 |
Echinococcus multilocularis | geminin | 0.0198 | 0.2443 | 0.2437 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0325 | 0.0784 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0281 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0118 | 0.011 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0059 | 0.0051 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0231 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0281 | 0.054 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.095 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0281 | 0.274 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0231 | 0.2201 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0231 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0333 | 0.0325 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0281 | 0.0273 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0333 | 0.0642 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.2443 | 0.4812 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0118 | 0.0218 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0333 | 0.0804 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0333 | 0.0642 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.003 | 0.0044 |
Schistosoma mansoni | lamin | 0.0033 | 0.0333 | 0.0642 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0059 | 0.01 |
Echinococcus granulosus | geminin | 0.0198 | 0.2443 | 0.4812 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.03 | 0.0578 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.03 | 0.0578 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.0685 | 0.1338 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0231 | 0.0535 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.03 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0111 | 0.0214 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.028 | 0.0537 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0212 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0281 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.014 | 0.0293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.