Detailed information for compound 1477548

Basic information

Technical information
  • TDR Targets ID: 1477548
  • Name: 1-[3-[(4-fluorophenyl)methoxy]phenyl]-N-(pyri din-4-ylmethyl)methanamine
  • MW: 322.376 | Formula: C20H19FN2O
  • H donors: 1 H acceptors: 1 LogP: 3.28 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)COc1cccc(c1)CNCc1ccncc1
  • InChi: 1S/C20H19FN2O/c21-19-6-4-17(5-7-19)15-24-20-3-1-2-18(12-20)14-23-13-16-8-10-22-11-9-16/h1-12,23H,13-15H2
  • InChiKey: PDMZJRHSPLGFQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-[(4-fluorophenyl)methoxy]phenyl]-N-(4-pyridylmethyl)methanamine
  • [3-(4-fluorobenzyl)oxybenzyl]-(4-pyridylmethyl)amine
  • STOCK5S-58337

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica prolyl oligopeptidase family protein 0.0046 0.0811 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0383 0.0287
Brugia malayi Importin beta-1 subunit 0.0032 0.0383 0.0283
Trypanosoma cruzi oligopeptidase b 0.0046 0.0811 0.0755
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0207 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0207 0.0207
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0383 0.0495
Giardia lamblia Alanyl dipeptidyl peptidase 0.0046 0.0811 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0 0.5
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0317 0.9264 1
Mycobacterium ulcerans hypothetical protein 0.0026 0.0207 0.2546
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0207 0.2546
Plasmodium falciparum importin beta, putative 0.0032 0.0383 0.4724
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0207 0.0094
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0046 0.0811 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0046 0.0811 0.0755
Toxoplasma gondii prolyl endopeptidase 0.0046 0.0811 0.1303
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0383 0.0287
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0046 0.0811 0.0699
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0207 0.0092
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0207 0.1241
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0046 0.0811 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0317 0.9264 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0207 0.1241
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0046 0.0811 0.0755
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0317 0.9264 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0207 0.2546
Entamoeba histolytica prolyl oligopeptidase family protein 0.0046 0.0811 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0046 0.0811 0.0755
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0046 0.0811 0.0755
Brugia malayi prolyl oligopeptidase family protein 0.0046 0.0811 0.0745
Loa Loa (eye worm) hypothetical protein 0.0026 0.0207 0.0207
Brugia malayi prolyl oligopeptidase family protein 0.0321 0.9391 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0121 0.149
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0207 0.0094
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0046 0.0811 1
Leishmania major oligopeptidase b 0.0046 0.0811 0.0755
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0046 0.0811 0.0755
Loa Loa (eye worm) hypothetical protein 0.0032 0.0383 0.0383
Brugia malayi hypothetical protein 0.0148 0.3999 0.4184
Loa Loa (eye worm) hypothetical protein 0.0148 0.3999 0.3999
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0046 0.0811 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0046 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0207 0.0207
Trypanosoma cruzi oligopeptidase b 0.0046 0.0811 0.0755
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0046 0.0811 1
Trypanosoma brucei oligopeptidase b 0.0046 0.0811 0.0755
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0121 0.149
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0193 0.5421 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0811 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0195 0.1078
Echinococcus granulosus acylamino acid releasing enzyme 0.0046 0.0811 0.0699
Plasmodium falciparum peptidase, putative 0.0046 0.0811 1
Brugia malayi prolyl oligopeptidase family protein 0.0317 0.9264 0.9863
Brugia malayi RNA, U transporter 1 0.0091 0.2216 0.226
Echinococcus granulosus Dipeptidyl peptidase 9 0.0317 0.9264 0.9255
Toxoplasma gondii hypothetical protein 0.0046 0.0811 0.1303
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0207 0.2546
Plasmodium vivax importin-beta 2, putative 0.0032 0.0383 0.4724
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0317 0.9264 0.9255
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0195 0.1078
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0046 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.4654 0.4654
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0046 0.0811 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0207 0.2546
Echinococcus granulosus importin subunit beta 1 0.0032 0.0383 0.0266
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0046 0.0811 0.0699
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0207 0.0094
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0383 0.0266
Echinococcus multilocularis prolyl endopeptidase 0.0046 0.0811 0.0699
Loa Loa (eye worm) hypothetical protein 0.0046 0.0811 0.0811
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0811 1
Trypanosoma cruzi prolyl endopeptidase 0.0046 0.0811 0.0755
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0321 0.9391 0.9384
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0195 0.0081
Loa Loa (eye worm) prolyl oligopeptidase 0.0046 0.0811 0.0811
Entamoeba histolytica hypothetical protein 0.0026 0.0195 0.1078
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0317 0.9264 1
Mycobacterium tuberculosis Probable peptidase 0.0046 0.0811 1
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0811 0.0755
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0207 0.2546
Loa Loa (eye worm) prolyl oligopeptidase 0.0321 0.9391 0.9391
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0317 0.9264 0.9255
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0195 0.1078
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0046 0.0811 0.0755
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0121 0.0121
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0046 0.0811 0.0699
Leishmania major importin beta-1 subunit, putative 0.0026 0.0195 0.0081
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0317 0.9264 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0321 0.9391 1
Trypanosoma brucei prolyl endopeptidase 0.0046 0.0811 0.0755
Schistosoma mansoni hypothetical protein 0.034 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0811 0.0755
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0321 0.9391 0.9384
Brugia malayi prolyl oligopeptidase family protein 0.0046 0.0811 0.0745
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0207 0.2546
Echinococcus multilocularis acylamino acid releasing enzyme 0.0046 0.0811 0.0699
Trypanosoma brucei prolyl oligopeptidase, putative 0.0046 0.0811 0.0755
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0046 0.0811 0.1303
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0207 0.0092
Entamoeba histolytica hypothetical protein, conserved 0.0046 0.0811 1
Schistosoma mansoni importin beta-1 0.0032 0.0383 0.0266
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0046 0.0811 0.0699
Giardia lamblia Alanyl dipeptidyl peptidase 0.0046 0.0811 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0207 0.2546
Echinococcus multilocularis snurportin 1 0.034 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0207 0.2546
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0207 0.2546
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0321 0.9391 0.9384
Echinococcus granulosus prolyl endopeptidase 0.0046 0.0811 0.0699
Onchocerca volvulus Prolyl endopeptidase homolog 0.0046 0.0811 0.0658
Loa Loa (eye worm) hypothetical protein 0.0046 0.0811 0.0811
Brugia malayi prolyl oligopeptidase family protein 0.0046 0.0811 0.0745
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0207 0.1241

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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