Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.0647 | 0.0492 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0196 | 0.1342 | 0.1342 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0932 | 1 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0282 | 0.2358 | 0.2231 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0786 | 0.8281 | 1 |
Loa Loa (eye worm) | reprolysin | 0.0096 | 0.0163 | 0.008 |
Echinococcus granulosus | adam 17 protease | 0.0201 | 0.14 | 0.1257 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.0694 | 0.0615 |
Onchocerca volvulus | Papilin homolog | 0.0181 | 0.1164 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 0.2163 | 0.2097 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0326 | 0.2867 | 0.2748 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0326 | 0.2867 | 0.2867 |
Schistosoma mansoni | glutaminase | 0.0266 | 0.2163 | 0.2163 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0183 | 0.1186 | 0.1186 |
Mycobacterium leprae | conserved hypothetical protein | 0.0146 | 0.0755 | 0.0746 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0163 | 0.008 |
Loa Loa (eye worm) | matrixin family protein | 0.0188 | 0.1245 | 0.1171 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0932 | 1 | 0.5 |
Brugia malayi | angiogenesis inhibito | 0.0189 | 0.1263 | 0.1218 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.0694 | 0.0539 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0587 | 0.5936 | 0.5916 |
Loa Loa (eye worm) | matrixin family protein | 0.0172 | 0.1062 | 0.0986 |
Onchocerca volvulus | Matrilysin homolog | 0.0172 | 0.1062 | 0.878 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0326 | 0.2867 | 0.2748 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0096 | 0.0163 | 0.0163 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0932 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0214 | 0.0131 |
Echinococcus multilocularis | adam 17 protease | 0.0183 | 0.1186 | 0.1039 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.0694 | 0.0694 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0115 | 0.0385 | 0.0225 |
Brugia malayi | Hemopexin family protein | 0.011 | 0.0331 | 0.0282 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0786 | 0.8281 | 1 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0096 | 0.0163 | 0.0163 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0932 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0172 | 0.1062 | 0.878 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0095 | 0.0148 | 0.0098 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0146 | 0.0755 | 0.0746 |
Echinococcus multilocularis | adam | 0.0196 | 0.1342 | 0.1198 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0974 | 0.0974 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0932 | 1 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0282 | 0.2358 | 0.2231 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0974 | 0.0824 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0786 | 0.8281 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0587 | 0.5936 | 0.5902 |
Mycobacterium ulcerans | glutaminase | 0.0266 | 0.2163 | 0.2478 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0932 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0974 | 0.0974 |
Brugia malayi | Matrixin family protein | 0.0188 | 0.1245 | 0.12 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.3553 | 0.3499 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1164 | 0.1089 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0283 | 0.2359 | 0.2719 |
Brugia malayi | hypothetical protein | 0.0196 | 0.1342 | 0.1298 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0932 | 1 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0266 | 0.2163 | 0.2123 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.0694 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0148 | 0.0065 |
Brugia malayi | ADAMTS-like protease | 0.0189 | 0.1263 | 0.1218 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.1127 | 0.1052 |
Echinococcus granulosus | adam | 0.0196 | 0.1342 | 0.1198 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0932 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 0.2163 | 0.2097 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0786 | 0.8281 | 1 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0786 | 0.8281 | 1 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0932 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.0974 | 0.0824 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0932 | 1 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0115 | 0.0385 | 0.0225 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0932 | 1 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0146 | 0.0755 | 0.0746 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0932 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.