Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0171 | 0.0315 | 0.0286 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0299 | 0.0688 | 0.1184 |
Loa Loa (eye worm) | TK protein kinase | 0.0146 | 0.0239 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0106 | 0.0106 |
Echinococcus granulosus | c src tyrosine kinase | 0.0082 | 0.0054 | 0.0024 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.2054 | 0.5813 | 0.5801 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0116 | 0.0154 | 0.0124 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0119 | 0.0162 | 0.0133 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.059 | 0.1537 | 0.2644 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.1356 | 0.3774 | 0.4227 |
Echinococcus multilocularis | bone morphogenetic protein 2 | 0.01 | 0.0106 | 0.0076 |
Echinococcus multilocularis | tgf beta family | 0.01 | 0.0106 | 0.0076 |
Schistosoma mansoni | nephrin | 0.0074 | 0.003 | 0.0051 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0082 | 0.0054 | 0.0024 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0171 | 0.0315 | 0.0286 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0146 | 0.0239 | 0.021 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0324 | 0.0761 | 0.0733 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0078 | 0.0042 | 0.0012 |
Schistosoma mansoni | tgf-beta family | 0.01 | 0.0106 | 0.0182 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0146 | 0.0239 | 0.021 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0171 | 0.0315 | 0.0286 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0146 | 0.0239 | 0.021 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0244 | 0.0528 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0082 | 0.0054 | 0.0024 |
Echinococcus multilocularis | anti dorsalizing morphogenetic protein 1a | 0.039 | 0.0954 | 0.0927 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit beta 1 | 0.0131 | 0.0197 | 0.0168 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0082 | 0.0054 | 0.0092 |
Echinococcus granulosus | roundabout 2 | 0.0093 | 0.0086 | 0.0056 |
Brugia malayi | SRC-1 | 0.0171 | 0.0315 | 0.0341 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0175 | 0.0325 | 0.0296 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit beta 1 | 0.0131 | 0.0197 | 0.0168 |
Giardia lamblia | 5-AMP-activated protein kinase, beta-1 subunit | 0.0244 | 0.0528 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0146 | 0.0239 | 0.0256 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.09 | 0.2443 | 0.242 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0244 | 0.0528 | 0.058 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0916 | 0.2488 | 1 |
Echinococcus granulosus | anti dorsalizing morphogenetic protein 1a | 0.039 | 0.0954 | 0.0927 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0171 | 0.0315 | 0.0286 |
Echinococcus multilocularis | activin receptor type | 0.3488 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0086 | 0.0083 |
Schistosoma mansoni | protein kinase subunit beta | 0.0244 | 0.0528 | 0.0908 |
Schistosoma mansoni | cell adhesion molecule | 0.0078 | 0.0042 | 0.0072 |
Brugia malayi | hypothetical protein | 0.01 | 0.0106 | 0.0106 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0171 | 0.0315 | 0.0286 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0244 | 0.0528 | 0.5 |
Onchocerca volvulus | 0.0871 | 0.2359 | 0.9456 | |
Echinococcus granulosus | TGF beta receptor type 1 | 0.2054 | 0.5813 | 0.5801 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0979 | 0.2672 | 0.2989 |
Schistosoma mansoni | tyrosine kinase | 0.0082 | 0.0054 | 0.0092 |
Leishmania major | hypothetical protein, conserved | 0.0244 | 0.0528 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0082 | 0.0054 | 0.0047 |
Schistosoma mansoni | tyrosine kinase | 0.0171 | 0.0315 | 0.0542 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0171 | 0.0315 | 0.0286 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0171 | 0.0315 | 0.0286 |
Schistosoma mansoni | tgf-beta family | 0.01 | 0.0106 | 0.0182 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0244 | 0.0528 | 0.058 |
Loa Loa (eye worm) | SRC-1 | 0.0171 | 0.0315 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0042 | 0.0034 |
Schistosoma mansoni | protein kinase | 0.1615 | 0.4531 | 0.7794 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0171 | 0.0315 | 0.0286 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0082 | 0.0054 | 0.0024 |
Schistosoma mansoni | protein kinase subunit beta | 0.0131 | 0.0197 | 0.0339 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.2515 | 0.7161 | 0.7152 |
Echinococcus granulosus | twitchin | 0.0077 | 0.004 | 0.001 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0238 | 0.0511 | 0.0561 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0171 | 0.0315 | 0.0286 |
Schistosoma mansoni | tyrosine kinase | 0.0171 | 0.0315 | 0.0542 |
Schistosoma mansoni | tyrosine kinase | 0.0082 | 0.0054 | 0.0092 |
Toxoplasma gondii | 5'-AMP-activated protein kinase subunit beta-1 family protein, putative | 0.0144 | 0.0235 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0324 | 0.0761 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0086 | 0.0083 |
Loa Loa (eye worm) | glutamate receptor | 0.0104 | 0.0117 | 0.0118 |
Onchocerca volvulus | Alicorn homolog | 0.0213 | 0.0437 | 0.1392 |
Brugia malayi | hypothetical protein | 0.01 | 0.0106 | 0.0106 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.022 | 0.0458 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 0.3764 | 0.4215 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.208 | 0.5889 | 0.6602 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.01 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 0.1601 | 0.1785 |
Echinococcus granulosus | tyrosine kinase | 0.0146 | 0.0239 | 0.021 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0979 | 0.2672 | 0.2989 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0106 | 0.0106 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0116 | 0.0154 | 0.0124 |
Loa Loa (eye worm) | bone morphogenic protein 6 | 0.039 | 0.0954 | 0.1058 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.2054 | 0.5813 | 0.5801 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.022 | 0.0458 | 0.043 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0146 | 0.0239 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0922 | 0.2507 | 0.2803 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0171 | 0.0315 | 0.0286 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0119 | 0.0162 | 0.0133 |
Echinococcus granulosus | AMPK beta subunit | 0.0244 | 0.0528 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.2268 | 0.2534 |
Entamoeba histolytica | protein kinase, putative | 0.0119 | 0.0162 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0263 | 0.0583 | 0.0642 |
Loa Loa (eye worm) | LjBmp2/4b | 0.3116 | 0.8914 | 1 |
Echinococcus granulosus | tgf beta family | 0.01 | 0.0106 | 0.0076 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0244 | 0.0528 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0146 | 0.0239 | 0.021 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0171 | 0.0315 | 0.0286 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0171 | 0.0315 | 0.0286 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0128 | 0.0189 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.0761 | 0.0842 |
Loa Loa (eye worm) | 5'-AMP-activated protein kinase | 0.0244 | 0.0528 | 0.058 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0171 | 0.0315 | 0.0286 |
Loa Loa (eye worm) | growth/differentiation factor 10 | 0.01 | 0.0106 | 0.0106 |
Echinococcus multilocularis | AMPK beta subunit | 0.0244 | 0.0528 | 0.0499 |
Loa Loa (eye worm) | TK protein kinase | 0.0119 | 0.0162 | 0.0169 |
Brugia malayi | Protein kinase domain containing protein | 0.2656 | 0.7572 | 0.8493 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0263 | 0.0583 | 0.0642 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0128 | 0.0189 | 0.0199 |
Echinococcus multilocularis | roundabout 2 | 0.0093 | 0.0086 | 0.0056 |
Brugia malayi | hypothetical protein | 0.1352 | 0.3764 | 0.4215 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.039 | 0.0954 | 0.1058 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0082 | 0.0054 | 0.5 |
Schistosoma mansoni | protein kinase | 0.2054 | 0.5813 | 1 |
Brugia malayi | protein C17H12.11 | 0.1352 | 0.3764 | 0.4215 |
Echinococcus granulosus | bone morphogenetic protein 2 | 0.01 | 0.0106 | 0.0076 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0082 | 0.0054 | 0.0024 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.022 | 0.0458 | 0.0788 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0171 | 0.0315 | 0.0286 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0082 | 0.0054 | 0.5 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.3116 | 0.8914 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0171 | 0.0315 | 0.0286 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.208 | 0.5889 | 0.6602 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.2656 | 0.7572 | 0.8493 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0171 | 0.0315 | 0.0286 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.